⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255887 | 1.00 | — | — | |
| SCHEMBL3706927 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL665365 | 0.97 | TSHR (0.44) | — | |
| Hydrochloric Acid SCHEMBL665366 | 0.97 | TSHR (0.44) | — | |
| Hydrochloric Acid SCHEMBL20305534 | 0.95 | TSHR (0.42) | — | |
| Methylene Chloride SCHEMBL28375080 | 0.91 | TSHR (0.39) | — | |
| SCHEMBL2607971 | 0.86 | — | — | |
| Maleic Acid SCHEMBL1756125 | 0.84 | TSHR (0.38) | — | |
| Maleic Acid SCHEMBL22367552 | 0.84 | TSHR (0.38) | — | |
| Maleic Acid SCHEMBL30806194 | 0.84 | TSHR (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1042 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4745152-A2 | PEPTIDES BINDING TO BFL-1 | Dana-Farber Cancer Institute, Inc. (US) | 2026-05-20 | — | — | EP | claimed |
| EP-3341008-B1 | PEPTIDES BINDING TO BFL-1 | DANA FARBER CANCER INST INC (US) | 2026-04-15 | — | — | EP | claimed |
| CN-117959959-A | Preparation of zwitterionic polymer modified hydrophilic polysulfone membrane | 青岛科技大学 | 2024-05-03 | — | — | CN | claimed |
| EP-3787629-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | Kinnate Biopharma Inc. (US) | 2021-03-10 | — | — | EP | claimed |
| US-20210053969-A1 | INHIBITORS OF CYCLIN-DEPENDENT KINASES | KINNATE BIOPHARMA INC. | 2021-02-25 | — | — | US | claimed |
| US-10550107-B2 | Process for the preparation of N-[4-[(3-chloro-4-fluoro phenyl) amino]-7-[[(3s-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethyl amino)-(2E)-2-butenamide (2Z)-2-butenedioate (1:2) and its polymorphs thereof | MSN LABORATORIES PRIVATE LIMITED (IN) | 2020-02-04 | — | — | US | claimed |
| US-20190002514-A1 | PEPTIDES BINDING TO BFL-1 | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-01-03 | — | — | US | claimed |
| US-20190002506-A1 | STABILIZED PEPTIDES FOR COVALENT BINDING TO TARGET PROTEIN | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2019-01-03 | — | — | US | claimed |
| US-20180297989-A1 | PROCESS FOR THE PREPARATION OF N-[4-[(3-CHLORO-4-FLUORO PHENYL) AMINO]-7-[[(3s-TETRAHYDRO-3-FURANYL]OXY]-6-QUINAZOLINYL]-4-(DIMETHYL AMINO)-(2E)-2-BUTENAMIDE (2Z)-2-BUTENEDIOATE (1 :2) AND ITS POLYMORPHS THEREOF | MSN LABORATORIES PRIVATE LIMITED (IN) | 2018-10-18 | — | — | US | claimed |
| EP-3341008-A2 | PEPTIDES BINDING TO BFL-1 | Dana-Farber Cancer Institute, Inc. (US) | 2018-07-04 | — | — | EP | claimed |
| WO-2001068186-A2 | USE OF CYANOQUINOLINES FOR TREATING OR INHIBITING COLONIC POLYPS | AMERICAN CYANAMID COMPANY (US) | 2001-09-20 | — | — | WO | claimed |
| US-6251912-B1 | Substituted quinazoline derivatives | AMERICAN CYANAMID COMPANY | 2001-06-26 | — | — | US | claimed |
| WO-2001012227-A1 | NSAID AND EFGR KINASE INHIBITOR CONTAINING COMPOSITION FOR THE TREATMENT OR INHIBITION OF COLONIC POLYPS AND COLORECTAL CANCER | AMERICAN CYANAMID COMPANY (US) | 2001-02-22 | — | — | WO | claimed |
| WO-2000066583-A1 | SUBSTITUTED 3-CYANO-[1.7], [1.5], AND [1.8]-NAPHTHYRIDINE INHIBITORS OF TYROSINE KINASES | AMERICAN CYANAMID COMPANY (US) | 2000-11-09 | — | — | WO | claimed |
| EP-1000039-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | American Cyanamid Company (US) | 2000-05-17 | — | — | EP | claimed |
| EP-0973746-A1 | SUBSTITUTED 3-CYANO QUINOLINES | American Cyanamid Company (US) | 2000-01-26 | — | — | EP | claimed |
| US-6002008-A | Substituted 3-cyano quinolines | AMERICAN CYANAMID COMPANY | 1999-12-14 | — | — | US | claimed |
| WO-1999009016-A1 | SUBSTITUTED QUINAZOLINE DERIVATIVES AND THEIR USE AS TYROSINE KINASE INHIBITORS | AMERICAN CYANAMID COMPANY (US) | 1999-02-25 | — | — | WO | claimed |
| WO-1998043960-A1 | SUBSTITUTED 3-CYANO QUINOLINES | AMERICAN CYANAMID COMPANY (US) | 1998-10-08 | — | — | WO | claimed |
| CN-85101686-A | 3-amino-2-benzoyl-acrylic acid derivatives manufacture method | — | 1986-07-30 | — | — | CN | claimed |