Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | HCAR1 | Q9BXC0 | 5/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 2/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12059745 | 0.89 | ACVR1 (0.50) | ACVR1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL2054288 | 0.84 | HSD17B10 (0.46) | ACVR1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL6920715 | 0.79 | ACVR1 (0.48) | ACVR1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL25151753 | 0.77 | ACVR1 (0.50) | ACVR1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL6921895 | 0.76 | GRM5 (0.49) | ACVR1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL25151758 | 0.76 | ACVR1 (0.49) | ACVR1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL25151865 | 0.76 | ACVR1 (0.49) | ACVR1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL25151871 | 0.76 | ACVR1 (0.49) | ACVR1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL25151867 | 0.76 | ACVR1 (0.49) | ACVR1HSD17B10KDM4ENPC1ALDH1A1 | |
| SCHEMBL6921950 | 0.76 | MAPK14 (0.47) | ALDH1A1SLC2A1MAPK14MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319380-A1 | Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof | SUNOVION PHARMACEUTICALS INC. (US) | 2011-12-29 | — | — | US | disclosed |
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319380-A1 | Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof | GRM5, GRM2, GRM1 | ACVR1 4208/4885HSD17B10 2253/4885KDM4E 2003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.