Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.66 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.62 |
| ▸ | CXCR1 | P25024 | 1/20 | 0.58 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 6/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | IDH2 | P48735 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595091 | 0.91 | CXCR1 (0.70) | TRPV1CXCR1CXCR2MEN1KMT2A | |
| SCHEMBL6823368 | 0.91 | CXCR1 (0.70) | TRPV1CXCR1CXCR2MEN1KMT2A | |
| SCHEMBL5468450 | 0.91 | TRPV1 (0.78) | TRPV1GRIK1CXCR1CXCR2MEN1 | |
| SCHEMBL1463349 | 0.86 | GSK3A (0.66) | TRPV1GRIK1MEN1KMT2AMAPT | |
| SCHEMBL7496033 | 0.85 | CXCR1 (0.65) | CXCR1CXCR2MEN1KMT2AMAPT | |
| SCHEMBL18013182 | 0.85 | TRPV1 (0.72) | TRPV1GRIK1MEN1KMT2AMAPT | |
| SCHEMBL6922530 | 0.83 | TRPV1 (0.48) | TRPV1GRIK1MEN1KMT2AMAPT | |
| SCHEMBL6763519 | 0.82 | MEN1 (0.70) | TRPV1CXCR1CXCR2MEN1KMT2A | |
| SCHEMBL1462991 | 0.82 | GRIK1 (0.76) | TRPV1GRIK1CXCR1CXCR2MEN1 | |
| SCHEMBL6371141 | 0.81 | TRPV1 (0.76) | TRPV1GRIK1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1185261-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-25 | — | — | EP | disclosed |
| EP-1185261-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000076495-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |