Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 8/20 | 0.48 |
| ▸ | PDE10A | Q9Y233 | 4/20 | 0.44 |
| ▸ | TNKS | O95271 | 3/20 | 0.43 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6921238 | 0.90 | PDE10A (0.49) | PARP1PDE10ATNKSPARP2TNKS2 | |
| SCHEMBL6920846 | 0.82 | PARP1 (0.46) | PARP1PDE10ATNKSPARP2PIM1 | |
| SCHEMBL6922724 | 0.79 | PARP1 (0.48) | PARP1PDE10ATNKSPARP2TNKS2 | |
| SCHEMBL6922750 | 0.78 | PARP1 (0.48) | PARP1PDE10APARP2TNKS2PARP14 | |
| SCHEMBL16261142 | 0.72 | PARP1 (0.56) | PARP1TNKS2ALDH1A1ALPLPARP14 | |
| SCHEMBL19116440 | 0.71 | KDM4C (0.59) | PARP1PDE10APARP2TNKS2ALDH1A1 | |
| SCHEMBL18824308 | 0.69 | PARP1 (0.67) | PARP1PDE10APARP2TNKS2SMN1; SMN2 | |
| SCHEMBL12066523 | 0.69 | PDE10A (0.58) | PARP1PDE10ATNKSPARP2TNKS2 | |
| SCHEMBL29040017 | 0.68 | SMN1; SMN2 (0.47) | PARP1TNKSPARP2SMN1; SMN2PARP14 | |
| SCHEMBL6790215 | 0.68 | PARP1 (0.54) | PARP1PDE10APARP2TNKS2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110319380-A1 | Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof | SUNOVION PHARMACEUTICALS INC. (US) | 2011-12-29 | — | — | US | disclosed |
| WO-2011075699-A2 | COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2011-06-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110319380-A1 | Compounds for Treating Disorders Mediated by Metabotropic Glutamate Receptor 5, and Methods of Use Thereof | GRM5, GRM2, GRM1 | PARP1 3551/4885PDE10A 1514/4885TNKS 2840/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.