Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 9/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 9/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.48 |
| ▸ | HTR1A | P08908 | 5/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.40 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3895131 | 0.85 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3HTR1ALTA4H | |
| SCHEMBL6926483 | 0.83 | GBA1 (0.55) | GBA1SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6922636 | 0.82 | SLC6A4 (0.50) | GBA1SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6922709 | 0.80 | GBA1 (0.50) | GBA1SLC6A2SLC6A4LTA4HHTR2C | |
| SCHEMBL7526770 | 0.79 | GBA1 (0.71) | GBA1SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6923984 | 0.79 | SLC6A2 (0.51) | GBA1SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6927394 | 0.78 | GBA1 (0.53) | GBA1SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6922681 | 0.78 | GBA1 (0.54) | GBA1SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6929247 | 0.77 | GBA1 (0.51) | GBA1SLC6A2SLC6A4SLC6A3HTR1A | |
| SCHEMBL6922705 | 0.77 | SLC6A4 (0.45) | GBA1SLC6A2SLC6A4SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518284-B2 | For inhibiting the serotonin and/or noradrenaline reuptake, and are useful as medicaments in disorders in which an increase of levels of those neurotransmitters is necessary | FAES, FABRICA ESPANOLA DE PRODUCTOS QUIMICOS Y FARMACEUTICOS S.A. (ES) | 2003-02-11 | — | — | US | claimed |
| EP-1002794-A1 | 4-[(Aryl)(aryloxy)methyl]piperidine derivatives and their use as serotonin and/or noradrenaline reuptake inhibitors | FAES, Fabrica Espanola de Productos Quimicos y Farmaceuticos, S.A. (ES) | 2000-05-24 | — | — | EP | claimed |