Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.69 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.56 |
| ▸ | SYK | P43405 | 1/20 | 0.50 |
| ▸ | SGMS1 | Q86VZ5 | 1/20 | 0.47 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.47 |
| ▸ | CTSC | P53634 | 1/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 3/20 | 0.44 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14804998 | 0.91 | EPHX2 (0.57) | EPHX2SGMS2SYKSGMS1DDR1 | |
| SCHEMBL6924124 | 0.91 | EPHX2 (0.57) | EPHX2SGMS2SYKSGMS1DDR1 | |
| SCHEMBL14805001 | 0.89 | EPHX2 (0.55) | EPHX2SGMS2SYKSGMS1DDR1 | |
| SCHEMBL2234534 | 0.86 | GRM4 (0.61) | EPHX2SGMS2GRM4 | |
| SCHEMBL2235274 | 0.81 | EPHX2 (0.74) | EPHX2CTSCGRM4EGFR | |
| SCHEMBL14804990 | 0.81 | GRM4 (0.51) | EPHX2SGMS2SGMS1GRM4 | |
| SCHEMBL6922905 | 0.80 | EPHX2 (0.60) | EPHX2SGMS2SGMS1GRM4EGFR | |
| SCHEMBL14804989 | 0.80 | EPHX2 (0.64) | EPHX2GRM4 | |
| SCHEMBL2235375 | 0.78 | GRM4 (0.58) | EPHX2SGMS2SYKSGMS1GRM4 | |
| SCHEMBL30754724 | 0.78 | SYK (0.63) | EPHX2SGMS2SYKCTSCPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8916584-B2 | Benzisoxazoles and azabenzisoxazoles as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction | VANDERBILT UNIVERSITY (US) | 2014-12-23 | — | — | US | disclosed |
| WO-2011100614-A1 | BENZISOXAZOLES AND AZABENZISOXAZOLES AS mgluR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |