SCHEMBL6923343

SCHEMBL6923343

N#Cc1cccc2c1c1nc(-c3cccc([N+](N)=O)c3)nc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c1n2CC(=O)N1CCOCC1

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ABCC1 P33527 20/20 0.47
CYP3A4 P08684 10/20 0.47
ABCB1 P08183 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6921769 0.84 ABCC1 (0.58) ABCC1CYP3A4
3-Nitroaniline SCHEMBL6923345 0.82 ABCC1 (0.55) ABCC1CYP3A4
SCHEMBL7128867 0.71 ABCC1 (0.64) ABCC1CYP3A4
SCHEMBL6924602 0.69 ABCC1 (0.60) ABCC1CYP3A4
SCHEMBL6919655 0.69 ABCC1 (0.68) ABCC1CYP3A4
SCHEMBL6922341 0.68 ABCC1 (0.59) ABCC1CYP3A4
SCHEMBL6826581 0.66 ABCC1 (0.74) ABCC1CYP3A4
SCHEMBL6826781 0.66 ABCC1 (0.76) ABCC1CYP3A4
SCHEMBL6923689 0.65 ABCC1 (0.75) ABCC1CYP3A4
SCHEMBL6923691 0.64 ABCC1 (0.70) ABCC1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004111052-A1 PYRROLOPYRIMIDINE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE (MDR) XENOVA LIMITED (GB) 2004-12-23 WO claimed