Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 8/20 | 0.64 |
| ▸ | EGFR | P00533 | 7/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.45 |
| ▸ | CD38 | P28907 | 2/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14867346 | 0.84 | GRM4 (0.60) | GRM4TRPA1 | |
| SCHEMBL15691438 | 0.79 | EGFR (0.58) | GRM4EGFRCSNK2A1KDRTRPA1 | |
| SCHEMBL6922868 | 0.78 | GRM4 (0.70) | GRM4 | |
| SCHEMBL29496460 | 0.75 | GRM4 (1.00) | GRM4 | |
| SCHEMBL6923456 | 0.75 | GRM4 (0.72) | GRM4TRPA1 | |
| SCHEMBL2360210 | 0.75 | GRM4 (1.00) | GRM4 | |
| SCHEMBL6923576 | 0.74 | GRM4 (1.00) | GRM4CSNK2A1TRPA1 | |
| SCHEMBL6922229 | 0.74 | GRM4 (0.58) | GRM4EGFRCSNK2A1TRPA1 | |
| SCHEMBL6923707 | 0.74 | GRM4 (1.00) | GRM4TRPA1 | |
| SCHEMBL31027147 | 0.67 | MAPK1 (0.51) | GRM4EGFRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011100607-A1 | PYRAZOLOPYRIDINE, PYRAZOLOPYRAZINE, PYRAZOLOPYRIMIDINE, PYRAZOLOTHIOPHENE AND PYRAZOLOTHIAZOLE COMPOUNDS AS MGLUR4 ALLOSTERIC POTENTIATORS, COMPOUNDS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |