Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.74 |
| ▸ | PIM1 | P11309 | 8/20 | 0.68 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.68 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | INSR | P06213 | 1/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.59 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.59 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | NAT1 | P18440 | 1/20 | 0.58 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.57 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6923574 | 1.00 | IGF1R (0.74) | IGF1RPIM1PIM2ADAMTS5MEN1 | |
| SCHEMBL6785380 | 0.86 | IGF1R (1.00) | IGF1RPIM1PIM2ADAMTS5INSR | |
| SCHEMBL6785383 | 0.86 | IGF1R (1.00) | IGF1RPIM1PIM2ADAMTS5INSR | |
| SCHEMBL6202184 | 0.85 | PIM1 (0.76) | IGF1RPIM1PIM2MEN1POLB | |
| SCHEMBL4033200 | 0.83 | PIM1 (0.67) | IGF1RPIM1PIM2ADAMTS5MEN1 | |
| SCHEMBL4209957 | 0.83 | PIM1 (0.67) | IGF1RPIM1PIM2ADAMTS5MEN1 | |
| SCHEMBL4033197 | 0.83 | PIM1 (0.67) | IGF1RPIM1PIM2ADAMTS5MEN1 | |
| SCHEMBL1250348 | 0.82 | PIM1 (1.00) | IGF1RPIM1PIM2ADAMTS5AKR1B1 | |
| SCHEMBL2548389 | 0.82 | PIM1 (1.00) | IGF1RPIM1PIM2ADAMTS5AKR1B1 | |
| SCHEMBL1250346 | 0.82 | PIM1 (1.00) | IGF1RPIM1PIM2ADAMTS5AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | claimed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | claimed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | claimed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | claimed |
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |