SCHEMBL6923648

SCHEMBL6923648

Cn1c2ccnc(N3CCCCC3)c2c2ncnc(N3CCN(CCc4ccc(F)c(F)c4)CC3)c21.Fc1ccc(CCN2CCN(c3ncnc4c3[nH]c3cccnc34)CC2)cc1F

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ABCC1 P33527 20/20 0.68
CYP3A4 P08684 11/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6824586 0.89 ABCC1 (0.85) ABCC1CYP3A4
SCHEMBL6922274 0.86 ABCC1 (0.75) ABCC1CYP3A4
SCHEMBL6826902 0.83 ABCC1 (0.87) ABCC1CYP3A4
SCHEMBL6826738 0.82 ABCC1 (1.00) ABCC1CYP3A4
SCHEMBL6922262 0.81 ABCC1 (0.82) ABCC1CYP3A4
SCHEMBL6920384 0.79 ABCC1 (0.79) ABCC1CYP3A4
SCHEMBL6917921 0.78 ABCC1 (1.00) ABCC1CYP3A4
SCHEMBL6921946 0.77 ABCC1 (0.78) ABCC1CYP3A4
SCHEMBL6922554 0.77 ABCC1 (0.79) ABCC1CYP3A4
SCHEMBL6922561 0.77 ABCC1 (1.00) ABCC1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004111052-A1 PYRROLOPYRIMIDINE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE (MDR) XENOVA LIMITED (GB) 2004-12-23 WO claimed