Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.66 |
| ▸ | GRM4 | Q14833 | 6/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | ARNT | P27540 | 1/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | RAPGEF3 | O95398 | 2/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6922789 | 0.87 | EPHX2 (0.67) | EPHX2GRM4KDRKITCYP1A2 | |
| SCHEMBL14804991 | 0.86 | EPHX2 (0.66) | EPHX2GRM4KDRFLT1CYP1A2 | |
| SCHEMBL2234997 | 0.85 | EPHX2 (0.60) | EPHX2GRM4CYP1A2MEN1KMT2A | |
| SCHEMBL6923970 | 0.83 | GRM4 (0.60) | EPHX2GRM4CYP1A2MEN1KMT2A | |
| SCHEMBL2236658 | 0.81 | EPHX2 (0.60) | EPHX2GRM4KDR | |
| SCHEMBL6922687 | 0.79 | EPHX2 (0.56) | EPHX2GRM4CYP1A2 | |
| SCHEMBL14804992 | 0.79 | GRM4 (0.59) | EPHX2GRM4RAPGEF4CYP1A2MEN1 | |
| SCHEMBL2235274 | 0.79 | EPHX2 (0.74) | EPHX2GRM4CYP1A2MEN1ALDH1A1 | |
| SCHEMBL2235367 | 0.79 | GRM4 (0.61) | EPHX2GRM4KDRPDGFRBKIT | |
| SCHEMBL2235375 | 0.78 | GRM4 (0.58) | EPHX2GRM4MEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011100614-A1 | BENZISOXAZOLES AND AZABENZISOXAZOLES AS mgluR4 ALLOSTERIC POTENTIATORS, COMPOSITIONS, AND METHODS OF TREATING NEUROLOGICAL DYSFUNCTION | VANDERBILT UNIVERSITY (US) | 2011-08-18 | — | — | WO | disclosed |