Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 18/20 | 0.59 |
| ▸ | EDNRB | P24530 | 14/20 | 0.59 |
| ▸ | DHPS | P49366 | 2/20 | 0.54 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.54 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.54 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.54 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4059929 | 0.82 | EDNRA (0.70) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL6924546 | 0.79 | EDNRA (0.59) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL6974318 | 0.79 | EDNRA (0.89) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL5653426 | 0.78 | EDNRA (0.71) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL4062095 | 0.78 | EDNRA (0.64) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL25637066 | 0.78 | EDNRA (0.84) | EDNRAEDNRB | |
| SCHEMBL14289226 | 0.78 | EDNRA (0.84) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL5631093 | 0.77 | EDNRA (0.64) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL7298083 | 0.74 | EDNRA (1.00) | EDNRAEDNRBDHPSABCC3ABCC4 | |
| SCHEMBL13281278 | 0.74 | EDNRA (1.00) | EDNRAEDNRBDHPSABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345920-A1 | NOVEL SULFAMIDES AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2003-09-24 | — | — | EP | disclosed |
| WO-2002053557-A1 | NOVEL SULFAMIDES AND THEIR USE AS ENDOTHELIN RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2002-07-11 | — | — | WO | disclosed |