SCHEMBL6925232

SCHEMBL6925232

OCc1nnc2c(Cl)c(N3CCC(c4ccccc4)CC3)ccn12

nearest known ligand 0.80

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 20/20 0.80
HTR2A P28223 6/20 0.66
CYP2C9 P11712 1/20 0.56
CYP2C19 P33261 1/20 0.56
SLC6A3 Q01959 1/20 0.56
SIGMAR1 Q99720 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL750618 0.89 GRM2 (1.00) GRM2HTR2ACYP2C9CYP2C19SLC6A3
SCHEMBL747486 0.88 GRM2 (1.00) GRM2HTR2ACYP2C9CYP2C19SLC6A3
SCHEMBL750835 0.86 GRM2 (1.00) GRM2HTR2ACYP2C9CYP2C19SLC6A3
SCHEMBL748209 0.86 GRM2 (0.78) GRM2HTR2ACYP2C9CYP2C19SLC6A3
SCHEMBL748490 0.86 GRM2 (0.80) GRM2HTR2ACYP2C9CYP2C19SLC6A3
SCHEMBL749694 0.84 GRM2 (0.79) GRM2HTR2ACYP2C9CYP2C19SLC6A3
SCHEMBL746961 0.84 GRM2 (0.81) GRM2HTR2ACYP2C9CYP2C19SLC6A3
SCHEMBL10321481 0.84 GRM2 (0.71) GRM2HTR2ACYP2C9CYP2C19SLC6A3
SCHEMBL10321732 0.83 GRM2 (0.74) GRM2HTR2ACYP2C9CYP2C19SLC6A3
SCHEMBL749426 0.81 GRM2 (0.88) GRM2HTR2ACYP2C9CYP2C19SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010130424-A9 1,2,4-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) 2011-01-27 WO disclosed
WO-2010130424-A1 1,2,3-TRIAZOLO [4,3-A] PYRIDINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OR PREVENTION OF NEUROLOGICAL AND PSYCHIATRIC DISORDERS ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC (US) 2010-11-18 WO disclosed