Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 10/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL274892 | 0.87 | NR1H4 (0.60) | TRPV1LMNAMAPTNR1H4 | |
| SCHEMBL5731865 | 0.86 | TRPV1 (0.61) | TRPV1LMNAMAPTNR1H4CYP1A2 | |
| SCHEMBL5732574 | 0.86 | TRPV1 (0.49) | TRPV1LMNAMAPTNPSR1NR1H4 | |
| SCHEMBL5732240 | 0.85 | TRPV1 (0.49) | TRPV1LMNAMAPTNPSR1NR1H4 | |
| SCHEMBL273045 | 0.79 | NR1H4 (0.62) | TRPV1MAPTNPSR1NR1H4 | |
| SCHEMBL5732428 | 0.79 | NR1H4 (0.47) | TRPV1LMNAMAPTNPSR1NR1H4 | |
| SCHEMBL272897 | 0.78 | NR1H4 (0.66) | TRPV1LMNAMAPTNPSR1NR1H4 | |
| SCHEMBL274686 | 0.78 | NR1H4 (0.66) | TRPV1LMNAMAPTNPSR1NR1H4 | |
| SCHEMBL273816 | 0.77 | NR1H4 (0.62) | TRPV1LMNAMAPTNR1H4MEN1 | |
| SCHEMBL274288 | 0.77 | TRPV1 (0.45) | TRPV1LMNANR1H4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1532153-B1 | AZEPINOINDOLE AND PYRIDOINDOLE DERIVATIVES AS PHARMACEUTICAL AGENTS | X CEPTOR THERAPEUTICS INC (US) | 2012-02-29 | — | — | EP | disclosed |