Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.46 |
| ▸ | MEN1 | O00255 | 8/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 4/20 | 0.42 |
| ▸ | ANO2 | Q9NQ90 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1954204 | 0.89 | MEN1 (0.47) | KMT2AMEN1RAB9ANLRP3NPC1 | |
| SCHEMBL1954397 | 0.89 | MEN1 (0.45) | KMT2AMEN1RAB9ANLRP3NPC1 | |
| SCHEMBL1954089 | 0.86 | MEN1 (0.51) | KMT2AMEN1RAB9ANLRP3NPC1 | |
| SCHEMBL6925697 | 0.86 | NPC1 (0.39) | KMT2AMEN1RAB9ANPC1TP53 | |
| SCHEMBL2180967 | 0.86 | MEN1 (0.46) | KMT2AMEN1RAB9ANLRP3NPC1 | |
| SCHEMBL1954798 | 0.85 | MEN1 (0.49) | KMT2AMEN1RAB9ANLRP3NPC1 | |
| SCHEMBL1951570 | 0.85 | MEN1 (0.44) | KMT2AMEN1RAB9ANLRP3NPC1 | |
| SCHEMBL1900123 | 0.85 | MEN1 (0.44) | KMT2AMEN1RAB9ANLRP3NPC1 | |
| SCHEMBL1894769 | 0.85 | MEN1 (0.50) | KMT2AMEN1RAB9ANLRP3NPC1 | |
| SCHEMBL1896499 | 0.85 | MEN1 (0.43) | KMT2AMEN1RAB9ANLRP3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130079348-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-03-28 | — | — | US | disclosed |
| US-20130079348-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2013-03-28 | — | — | US | disclosed |
| WO-2011109551-A2 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA INC. (US) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130079348-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | KMT2A 4706/4885MEN1 2958/4885RAB9A 1174/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.