Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.53 |
| ▸ | PIM1 | P11309 | 7/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.48 |
| ▸ | CISD1 | Q9NZ45 | 5/20 | 0.47 |
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6926879 | 0.92 | AKR1B1 (0.53) | AKR1B1PIM1PIM2PIM3CISD1 | |
| SCHEMBL6926876 | 0.92 | AKR1B1 (0.53) | AKR1B1PIM1PIM2PIM3CISD1 | |
| SCHEMBL6928700 | 0.82 | PIM1 (0.55) | AKR1B1PIM1PIM2PIM3CISD1 | |
| SCHEMBL6930893 | 0.82 | PIM1 (0.55) | AKR1B1PIM1PIM2PIM3CISD1 | |
| SCHEMBL6928703 | 0.82 | PIM1 (0.55) | AKR1B1PIM1PIM2PIM3CISD1 | |
| SCHEMBL6930895 | 0.82 | PIM1 (0.55) | AKR1B1PIM1PIM2PIM3CISD1 | |
| SCHEMBL6928941 | 0.82 | AKR1B1 (0.48) | AKR1B1PIM1PIM2PIM3CISD1 | |
| SCHEMBL6928944 | 0.82 | AKR1B1 (0.48) | AKR1B1PIM1PIM2PIM3CISD1 | |
| SCHEMBL6927555 | 0.80 | GSK3B (0.51) | AKR1B1PIM1PIM2PIM3CISD1 | |
| SCHEMBL6927557 | 0.80 | GSK3B (0.51) | AKR1B1PIM1PIM2PIM3CISD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |