Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 19/20 | 0.42 |
| ▸ | HTR2B | P41595 | 16/20 | 0.42 |
| ▸ | HTR2A | P28223 | 5/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2576881 | 0.91 | HTR2C (0.40) | HTR2CHTR2BHTR2A | |
| SCHEMBL693012 | 0.88 | HTR2C (0.49) | HTR2CHTR2BHTR2A | |
| SCHEMBL3624384 | 0.87 | HTR2C (0.54) | HTR2CHTR2BHTR2A | |
| SCHEMBL692999 | 0.87 | HTR2C (0.43) | HTR2CHTR2BHTR2A | |
| SCHEMBL3627013 | 0.87 | HTR2C (0.44) | HTR2CHTR2BHTR2A | |
| SCHEMBL3629595 | 0.86 | HTR2C (0.47) | HTR2CHTR2BHTR2A | |
| SCHEMBL3627752 | 0.84 | HTR2C (0.57) | HTR2CHTR2BHTR2A | |
| SCHEMBL2016120 | 0.82 | HTR2C (0.42) | HTR2CHTR2BHTR2A | |
| SCHEMBL2017858 | 0.82 | HTR2C (0.39) | HTR2CHTR2BHTR2A | |
| SCHEMBL2014311 | 0.82 | HTR2C (0.39) | HTR2CHTR2BHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150607-A1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | AbbVie Inc. (US) | 2017-04-05 | — | — | EP | claimed |
| EP-2421870-B1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBVIE INC (US) | 2016-03-09 | — | — | EP | claimed |
| EP-2522671-B1 | Modulators of 5-HT receptors and methods of use thereof | ABBVIE INC (US) | 2016-01-20 | — | — | EP | claimed |
| EP-2560973-B1 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | ABBVIE INC (US) | 2016-11-16 | — | — | EP | disclosed |
| EP-2522671-B1 | Modulators of 5-HT receptors and methods of use thereof | ABBVIE INC (US) | 2016-01-20 | — | — | EP | disclosed |
| EP-2522671-A2 | Modulators of 5-HT receptors and methods of use thereof | Abbott Laboratories (US) | 2012-11-14 | — | — | EP | disclosed |
| EP-2421870-A2 | MODULATORS OF 5-HT RECEPTORS AND METHODS OF USE THEREOF | Abbott Laboratories (US) | 2012-02-29 | — | — | EP | disclosed |