Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 12/20 | 0.71 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.58 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.58 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.57 |
| ▸ | HTR2C | P28335 | 1/20 | 0.55 |
| ▸ | PLG | P00747 | 1/20 | 0.54 |
| ▸ | PLAU | P00749 | 1/20 | 0.54 |
| ▸ | PLAT | P00750 | 1/20 | 0.54 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927364 | 0.91 | MCHR1 (0.70) | MCHR1ABCB1SETD7ABCC1HTR2C | |
| SCHEMBL6927024 | 0.89 | MCHR1 (0.66) | MCHR1SETD7HTR2CALOX5 | |
| SCHEMBL6925692 | 0.87 | MCHR1 (0.92) | MCHR1HTR2C | |
| SCHEMBL6925343 | 0.87 | MCHR1 (0.77) | MCHR1HTR2CPLGPLAUPLAT | |
| SCHEMBL6921439 | 0.83 | MCHR1 (0.78) | MCHR1HTR2CKDR | |
| SCHEMBL6927209 | 0.83 | MCHR1 (0.78) | MCHR1HTR2CKDR | |
| SCHEMBL7913510 | 0.83 | MCHR1 (0.66) | MCHR1ABCB1HTR2CKDR | |
| SCHEMBL6924093 | 0.82 | MCHR1 (0.76) | MCHR1HTR2CKDR | |
| SCHEMBL6921907 | 0.81 | MCHR1 (0.80) | MCHR1HTR2C | |
| SCHEMBL6926140 | 0.80 | MCHR1 (0.72) | MCHR1HTR2CKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6515027-B1 | Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 | SMITHKLINE BEECHAM CORP. | 2003-02-04 | — | — | US | claimed |
| EP-4143235-A1 | METHODS AND COMPOSITIONS FOR TREATING CYTOKINE STORM INFECTIONS, INCLUDING COVID-19, BY INHIBITING CCR5/CCL5 INTERACTION | IncellDx, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |
| WO-2021222069-A1 | METHODS AND COMPOSITIONS FOR TREATING CYTOKINE STORM INFECTIONS, INCLUDING COVID-19, BY INHIBITING CCR5/CCL5 INTERACTION | INCELLDX, INC. (US) | 2021-11-04 | — | — | WO | disclosed |
| US-6515027-B1 | Ligands, agonists or antagonists, of the CC chemokine receptor CC-CKR5 | SMITHKLINE BEECHAM CORP. | 2003-02-04 | — | — | US | disclosed |