Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 6/20 | 0.70 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | TDP2 | O95551 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12767014 | 0.83 | ERN1 (1.00) | ERN1 | |
| SCHEMBL12767867 | 0.80 | ERN1 (1.00) | ERN1KEAP1 | |
| SCHEMBL28269364 | 0.78 | ERN1 (0.54) | ERN1KAT6APGRTAAR1KEAP1 | |
| SCHEMBL12121599 | 0.77 | ERN1 (0.62) | ERN1PGRTAAR1KEAP1PIK3R1 | |
| SCHEMBL15009764 | 0.77 | ERN1 (0.77) | ERN1PGRTAAR1KEAP1PIK3R1 | |
| SCHEMBL4036698 | 0.76 | ERN1 (0.68) | ERN1KEAP1PIK3R1PIK3CA | |
| SCHEMBL20462888 | 0.74 | ERN1 (0.46) | ERN1KAT6APGRTAAR1KEAP1 | |
| SCHEMBL1125758 | 0.73 | ERN1 (0.50) | ERN1 | |
| SCHEMBL4037959 | 0.73 | ERN1 (0.49) | ERN1PIK3R1PIK3CACYP3A4 | |
| SCHEMBL9901972 | 0.72 | ERN1 (0.50) | ERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| CN-1321153-A | telomerase inhibitors and methods of use thereof | GERON CORP (US) | 2001-11-07 | — | — | CN | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |