Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.49 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.49 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.49 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.49 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.49 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928447 | 1.00 | KDM4E (0.58) | KDM4ERECQLSMN1; SMN2HTTKMT2A | |
| SCHEMBL2178427 | 0.91 | KDM4E (0.68) | KDM4ERECQLSMN1; SMN2HTTKMT2A | |
| SCHEMBL7893069 | 0.84 | SMN1; SMN2 (0.81) | KDM4ERECQLSMN1; SMN2HTTKMT2A | |
| SCHEMBL14842266 | 0.84 | SMN1; SMN2 (0.75) | KDM4ERECQLSMN1; SMN2HTTKMT2A | |
| SCHEMBL9015423 | 0.83 | KDM4E (0.58) | KDM4ERECQLSMN1; SMN2HTTKMT2A | |
| SCHEMBL6928450 | 0.83 | KDM4E (0.58) | KDM4ERECQLSMN1; SMN2HTTKMT2A | |
| SCHEMBL7562761 | 0.83 | SMN1; SMN2 (0.79) | KDM4ERECQLSMN1; SMN2HTTKMT2A | |
| SCHEMBL9015380 | 0.80 | KDM4E (0.58) | KDM4ERECQLSMN1; SMN2HTTKMT2A | |
| SCHEMBL14842518 | 0.80 | KDM4E (0.58) | KDM4ERECQLSMN1; SMN2HTTKMT2A | |
| Hydrochloric Acid SCHEMBL7531582 | 0.79 | KDM4E (0.56) | KDM4ERECQLSMN1; SMN2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150963-B1 | SUBSTITUTED 4-AMINO-2-ARYLTETRAHYDROQUINAZOLINES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | AVENTIS PHARMA GMBH (DE) | 2003-12-03 | — | — | EP | disclosed |