Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.52 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.52 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.49 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.49 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692870 | 1.00 | CYSLTR2 (0.52) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 | |
| SCHEMBL29055600 | 0.94 | CYSLTR2 (0.50) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 | |
| SCHEMBL13983960 | 0.91 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 | |
| SCHEMBL21813151 | 0.90 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 | |
| SCHEMBL14843128 | 0.89 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 | |
| SCHEMBL30497375 | 0.89 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 | |
| SCHEMBL201961 | 0.89 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 | |
| SCHEMBL201960 | 0.89 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 | |
| SCHEMBL29517073 | 0.89 | CYSLTR2 (0.49) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 | |
| SCHEMBL13950635 | 0.88 | CYSLTR2 (0.50) | CYSLTR2CYSLTR1PTGER1PTGER4PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2203557-B1 | KETOREDUCTASE POLYPEPTIDES AND USES THEREOF | CODEXIS INC (US) | 2012-02-29 | — | — | EP | claimed |
| CN-112724082-B | Preparation method of montelukast sodium drug intermediate | 江苏阿尔法药业股份有限公司 | 2022-05-13 | — | — | CN | disclosed |
| CN-112724082-A | Preparation method of montelukast sodium drug intermediate | 江苏阿尔法药业有限公司 | 2021-04-30 | — | — | CN | disclosed |
| US-8617853-B2 | Ketoreductase polypeptides for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hydroxypropyl)benzoate | CODEXIS, INC. (US) | 2013-12-31 | — | — | US | disclosed |
| US-20120184000-A1 | KETOREDUCTASE POLYPEPTIDES FOR THE PRODUCTION OF (S,E)-METHYL 2-(3-(3-(2-(7-CHLOROQUINOLIN-2-YL)VINYL)PHENYL)-3-HYDROXYPROPYL)BENZOATE | CODEXIS, INC. (US) | 2012-07-19 | — | — | US | disclosed |
| EP-2276739-A1 | PROCESS FOR MAKING MONTELUKAST INTERMEDIATES | Synthon B.V. (NL) | 2011-01-26 | — | — | EP | disclosed |
| WO-2009130056-A1 | PROCESS FOR MAKING MONTELUKAST INTERMEDIATES | SYNTHON B.V. (NL) | 2009-10-29 | — | — | WO | disclosed |
| EP-2094665-A2 | PREPARATION OF MONTELUKAST AND ITS SALTS | Dr. Reddy's Laboratories Ltd. (IN) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008058118-A2 | PREPARATION OF MONTELUKAST AND ITS SALTS | DR. REDDY'S LABORTORIES, LTD. (IN) | 2008-05-15 | — | — | WO | disclosed |
| WO-2006021974-A1 | A PROCESS FOR SYNTHESIZING DIOL (VIII)-AN INTERMEDIATE OF MONTELUKAST SODIUM | MOREPEN LABORATORIES LIMITED (IN) | 2006-03-02 | — | — | WO | disclosed |
| EP-0480717-A1 | Unsaturated hydroxyalkylquinoline acids as leukotriene antagonists | MERCK FROSST CANADA INC. (CA) | 1992-04-15 | — | — | EP | disclosed |