SCHEMBL6928722

SCHEMBL6928722

O=C(O)CCc1cc2ccccc2cc1-c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
PTGER4 P35408 5/20 0.55
PTGER3 P43115 5/20 0.55
PTGER1 P34995 4/20 0.55
PTGER2 P43116 4/20 0.55
CCNC P24863 1/20 0.52
CDK8 P49336 1/20 0.52
FFAR1 O14842 7/20 0.49
FFAR4 Q5NUL3 5/20 0.48
KDM4E B2RXH2 1/20 0.47
CYP1A2 P05177 2/20 0.46
KEAP1 Q14145 1/20 0.46
CYP11B1 P15538 1/20 0.45
CYP11B2 P19099 1/20 0.45
PRKAG1 P54619 1/20 0.44
PRKAA2 P54646 1/20 0.44
PRKAB1 Q9Y478 1/20 0.44
NPSR1 Q6W5P4 1/20 0.43
CYP2C9 P11712 1/20 0.42
HSD17B10 Q99714 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5902874 0.82 FFAR1 (0.51) PTGER4PTGER3PTGER1PTGER2CCNC
SCHEMBL31212507 0.78 PTGER4 (0.77) PTGER4PTGER3PTGER1PTGER2FFAR1
SCHEMBL1261128 0.78 PTGER4 (0.77) PTGER4PTGER3PTGER1PTGER2FFAR1
SCHEMBL4273930 0.77 CYP1A2 (0.47) PTGER4PTGER3PTGER1PTGER2CCNC
SCHEMBL3840320 0.77 IDO1 (0.50) PTGER4PTGER3PTGER1PTGER2CCNC
SCHEMBL14430419 0.77 FFAR1 (0.56) PTGER4PTGER3PTGER1PTGER2CCNC
SCHEMBL5440013 0.77 FFAR4 (0.66) PTGER4PTGER3PTGER1PTGER2FFAR1
SCHEMBL3746360 0.77 FFAR4 (0.66) PTGER4PTGER3PTGER1PTGER2FFAR1
SCHEMBL8479912 0.77 PTGER4 (0.70) PTGER4PTGER3PTGER1PTGER2CCNC
SCHEMBL6053663 0.77 PTGER4 (0.81) PTGER4PTGER3PTGER1PTGER2FFAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6515142-B2 Intermediates of aromatic amidine derivatives which have anticoagulation action DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2003-02-04 US disclosed
US-20020062033-A1 Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-05-23 US disclosed
US-6337405-B1 MULTISTAGE REACTION OF PYRROLE SUBSTITUTED WITH SULFONATE GROUPS AND HYDROXYPHENYLACETIC ACID DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2002-01-08 US disclosed
US-6252088-B1 COUPLING A NITRILE CONTAININ NAPHTHALENE COMPOUND WITH A COMPOUND CONTAINING PROPIONIC ACID GROUP DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2001-06-26 US disclosed
EP-0936215-A1 PROCESS FOR PREPARING 2-PHENYL-3-NAPHTHYLPROPIONIC ACID DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1999-08-18 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020062033-A1 Process for preparing 2-phenyl-3-naphthylpropionic acid derivatives PROC, F12, F2 PTGER4 3009/4885PTGER3 2076/4885PTGER1 2451/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.