Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30635207 | 1.00 | GRM5 (0.59) | GRM5LMNATDP1 | |
| SCHEMBL2193806 | 0.87 | GRM5 (0.60) | GRM5LMNATDP1 | |
| SCHEMBL30079970 | 0.85 | GRM5 (0.59) | GRM5 | |
| SCHEMBL4155509 | 0.84 | PARP10 (0.51) | GRM5 | |
| SCHEMBL177837 | 0.81 | MAOB (0.50) | GRM5 | |
| SCHEMBL30635200 | 0.80 | GRM5 (0.50) | GRM5 | |
| SCHEMBL15556982 | 0.79 | CDK8 (0.46) | — | |
| SCHEMBL23900346 | 0.79 | USP2 (0.50) | GRM5 | |
| SCHEMBL29757280 | 0.79 | USP2 (0.50) | GRM5 | |
| SCHEMBL257972 | 0.79 | MAPT (0.48) | GRM5LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035186-A1 | SUBSTITUTED HETEROARYLAMIDE ANALOGS AS MGLUR5 NEGATIVE ALLOSTERIC MODULATORS AND METHODS OF MAKING AND USING THE SAME | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |