Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TYMP | P19971 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.32 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.32 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934734 | 0.99 | KDM4E (0.37) | KDM4ETYMPALDH1A1MEN1KMT2A | |
| SCHEMBL6929037 | 0.96 | KDM4E (0.38) | KDM4ETYMPALDH1A1MEN1KMT2A | |
| SCHEMBL6930727 | 0.94 | KDM4E (0.38) | KDM4ETYMPALDH1A1MEN1KMT2A | |
| SCHEMBL6933233 | 0.89 | KDM4E (0.35) | KDM4ETYMPALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL25233120 | 0.89 | TYMP (0.42) | KDM4ETYMPALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL26677042 | 0.89 | TYMP (0.42) | KDM4ETYMPALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL5962998 | 0.89 | KDM4E (0.37) | KDM4ETYMPALDH1A1MEN1KMT2A | |
| SCHEMBL5963301 | 0.88 | KDM4E (0.37) | KDM4ETYMPALDH1A1MEN1KMT2A | |
| SCHEMBL17222397 | 0.87 | KDM4E (0.47) | KDM4ETYMPTAS1R3TAS1R1TAAR1 | |
| SCHEMBL5963153 | 0.85 | TYMP (0.42) | KDM4ETYMPALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651759-B1 | NOVEL 2'-O-ALKYL NUCLEOSIDES AND PHOSPHORAMIDITES PROCESSES FOR THE PREPARATION AND USES THEREOF | ISIS PHARMACEUTICALS INC (US) | 2003-12-10 | — | — | EP | disclosed |
| EP-1223173-A2 | Novel 2'-O-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof | ISIS PHARMACEUTICALS, INC. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-6133438-A | Process for the preparation of 2'-O-alkyl purine phosphoramidites | ISIS PHARMACEUTICALS, INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-5914396-A | 2'-O-modified nucleosides and phosphoramidites | ISIS PHARMACEUTICALS, INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5856466-A | Process for the preparation of 2'-O-alkyl purine phosphoramidites | ISIS PHARMACEUTICALS, INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5646265-A | Process for the preparation of 2'-O-alkyl purine phosphoramidites | ISIS PHARMCEUTICALS, INC. (US) | 1997-07-08 | — | — | US | disclosed |