SCHEMBL6929328

SCHEMBL6929328

CN1CCN(c2cccc(Nc3cc(NC4CC4)n4ncc(/C=C5\NC(=O)NC5=O)c4n3)c2)CC1

nearest known ligand 0.47

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CSNK2A2 P19784 19/20 0.47
CSNK2B P67870 3/20 0.44
CSNK2A1 P68400 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12645943 0.92 CSNK2A2 (0.48) CSNK2A2CSNK2BCSNK2A1
SCHEMBL12645931 0.87 CSNK2B (0.40) CSNK2A2CSNK2BCSNK2A1
SCHEMBL12644915 0.86 CSNK2A2 (0.47) CSNK2A2CSNK2BCSNK2A1
SCHEMBL12587912 0.86 CSNK2A1 (0.45) CSNK2A1
SCHEMBL12587905 0.85 CSNK2A2 (0.53) CSNK2A2CSNK2BCSNK2A1
SCHEMBL2028667 0.85 CSNK2A2 (0.46) CSNK2A2CSNK2BCSNK2A1
SCHEMBL12583206 0.85 CSNK2B (0.47) CSNK2A2CSNK2BCSNK2A1
SCHEMBL1934393 0.85 CSNK2A2 (0.46) CSNK2A2CSNK2BCSNK2A1
SCHEMBL2031097 0.85 CSNK2B (0.47) CSNK2A2CSNK2BCSNK2A1
SCHEMBL2032305 0.85 CSNK2A2 (0.46) CSNK2A2CSNK2BCSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2509602-B9 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS SENHWA BIOSCIENCES INC (TW) 2017-11-01 EP disclosed
EP-2509602-B1 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS SENHWA BIOSCIENCES INC (TW) 2017-01-25 EP disclosed
US-9303033-B2 Pyrazolopyrimidines and related heterocycles as CK2 inhibitors SENHWA BIOSCIENCES, INC. (TW) 2016-04-05 US disclosed
US-9303033-B2 Pyrazolopyrimidines and related heterocycles as CK2 inhibitors SENHWA BIOSCIENCES, INC. (TW) 2016-04-05 US disclosed
US-8575177-B2 Pyrazolopyrimidines and related heterocycles as CK2 inhibitors SENHWA BIOSCIENCES, INC. (TW) 2013-11-05 US disclosed
WO-2012170827-A2 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS CYLENE PHARMACEUTICALS, INC. (US) 2012-12-13 WO disclosed
WO-2011068667-A1 PYRAZOLOPYRIMIDINES AND RELATED HETEROCYCLES AS CK2 INHIBITORS CYLENE PHARMACEUTICALS, INC. (US) 2011-06-09 WO disclosed