Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.52 |
| ▸ | CISD1 | Q9NZ45 | 5/20 | 0.51 |
| ▸ | MAOB | P27338 | 3/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | PIM1 | P11309 | 7/20 | 0.50 |
| ▸ | PIM2 | Q9P1W9 | 7/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6929394 | 1.00 | AKR1B1 (0.52) | AKR1B1CISD1MAOBPIK3CDNPC1 | |
| SCHEMBL6928941 | 0.90 | AKR1B1 (0.48) | AKR1B1CISD1MAOBPIK3CDNPC1 | |
| SCHEMBL6928944 | 0.90 | AKR1B1 (0.48) | AKR1B1CISD1MAOBPIK3CDNPC1 | |
| SCHEMBL6927557 | 0.82 | GSK3B (0.51) | AKR1B1CISD1MAOBPIM1PIM2 | |
| SCHEMBL6927555 | 0.82 | GSK3B (0.51) | AKR1B1CISD1MAOBPIM1PIM2 | |
| SCHEMBL6928700 | 0.80 | PIM1 (0.55) | AKR1B1CISD1MAOBPIM1PIM2 | |
| SCHEMBL6930893 | 0.80 | PIM1 (0.55) | AKR1B1CISD1MAOBPIM1PIM2 | |
| SCHEMBL6930895 | 0.80 | PIM1 (0.55) | AKR1B1CISD1MAOBPIM1PIM2 | |
| SCHEMBL6928703 | 0.80 | PIM1 (0.55) | AKR1B1CISD1MAOBPIM1PIM2 | |
| SCHEMBL6926876 | 0.79 | AKR1B1 (0.53) | AKR1B1CISD1MAOBPIM1PIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6518268-B1 | Telomerase inhibitors and methods of their use | GERON CORPORATION | 2003-02-11 | — | — | US | disclosed |
| WO-2001002377-A9 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORP (US) | 2001-10-11 | — | — | WO | disclosed |
| EP-1109796-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | Geron Corporation (US) | 2001-06-27 | — | — | EP | disclosed |
| WO-2001002377-A1 | TELOMERASE INHIBITORS AND METHODS OF THEIR USE | GERON CORPORATION (US) | 2001-01-11 | — | — | WO | disclosed |