SCHEMBL6929667

SCHEMBL6929667

CCc1ccc(C(O)COc2ccc(CC3(C)SC(=O)NC3=O)cc2)nc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 9/20 0.64
CYP3A4 P08684 2/20 0.40
RXRA P19793 1/20 0.40
MPC2 O95563 1/20 0.39
CYP2C8 P10632 1/20 0.39
CYP2C9 P11712 1/20 0.39
GRIN2B Q13224 1/20 0.35
MMP2 P08253 1/20 0.33
MMP3 P08254 1/20 0.33
MMP9 P14780 1/20 0.33
ALDH1A1 P00352 2/20 0.32
CISD1 Q9NZ45 1/20 0.32
LMNA P02545 2/20 0.32
MEN1 O00255 1/20 0.32
KMT2A Q03164 1/20 0.32
SOD1 P00441 1/20 0.31
HSD11B1 P28845 1/20 0.31
CYP26A1 O43174 1/20 0.30
CYP26B1 Q9NR63 1/20 0.30
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6930220 1.00 PPARG (0.64) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL6928300 1.00 PPARG (0.64) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL21504696 0.89 PPARG (0.53) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL6930478 0.89 PPARG (0.50) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL12628859 0.88 PPARG (0.50) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL14408623 0.88 PPARG (0.50) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL23836845 0.87 PPARG (0.66) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL18541509 0.87 PPARG (0.66) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL6931166 0.85 PPARG (0.48) PPARGCYP3A4RXRAMPC2CYP2C8
SCHEMBL6931096 0.85 PPARG (0.48) PPARGCYP3A4RXRAMPC2CYP2C8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220211682-A1 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME DEUTERX, LLC 2022-07-07 US disclosed
US-11123336-B2 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same POXEL SA (FR) 2021-09-21 US disclosed
US-10265305-B2 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same POXEL SA (FR) 2019-04-23 US disclosed
US-20180133204-A1 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME POXEL SA (FR) 2018-05-17 US disclosed
US-9833445-B2 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same DEUTERX, LLC (US) 2017-12-05 US disclosed
EP-3202401-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES Octeta Therapeutics, LLC (US) 2017-08-09 EP disclosed
US-20170049762-A1 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME POXEL SA (FR) 2017-02-23 US disclosed
EP-2512470-B1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES OCTETA THERAPEUTICS LLC (US) 2016-11-30 EP disclosed
US-20160051529-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES CIRIUS THERAPEUTICS, INC. 2016-02-25 US disclosed
US-20160051529-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES CIRIUS THERAPEUTICS, INC. 2016-02-25 US disclosed
WO-2011084453-A1 PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) 2011-07-14 WO disclosed
WO-2011084459-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF OBESITY AND OTHER METABOLIC DISEASES METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) 2011-07-14 WO disclosed
WO-2011084456-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) 2011-07-14 WO disclosed
WO-2011075514-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) 2011-06-23 WO disclosed
US-20090143441-A1 Combination therapies of Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY 2009-06-04 US disclosed
US-20090143441-A1 Combination therapies of Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY 2009-06-04 US disclosed
US-20090143442-A1 Thiazolidinedione analogues ALZHEIMER DRUG DISCOVERY FOUNDATION 2009-06-04 US disclosed
US-20090143442-A1 Thiazolidinedione analogues ALZHEIMER DRUG DISCOVERY FOUNDATION 2009-06-04 US disclosed
US-20090137638-A1 Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC 2009-05-28 US disclosed
US-20090137638-A1 Thiazolidinedione analogues METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC 2009-05-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10265305-B2 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same SLC5A2, PPARD, DPP4 PPARG 10/4885CYP3A4 108/4885RXRA 213/4885
US-20090143442-A1 Thiazolidinedione analogues PPARD, GLP1R, PPARG PPARG 3/4885CYP3A4 727/4885RXRA 435/4885
US-20090143441-A1 Combination therapies of Thiazolidinedione analogues GLP1R, PPARD, SLC5A2 PPARG 5/4885CYP3A4 1170/4885RXRA 218/4885
US-20160051529-A1 PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER METABOLIC DISEASES PPARD, PPARG, PPARA PPARG 2/4885CYP3A4 685/4885RXRA 27/4885
US-20090137638-A1 Thiazolidinedione analogues SLC5A2, GLP1R, SLC5A1 PPARG 6/4885CYP3A4 1017/4885RXRA 346/4885
US-20220211682-A1 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME SLC5A2, PPARD, DPP4 PPARG 10/4885CYP3A4 108/4885RXRA 213/4885
US-20180133204-A1 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME SLC5A2, PPARD, DPP4 PPARG 10/4885CYP3A4 108/4885RXRA 213/4885
US-11123336-B2 5-deutero-2,4-thiazolidinedione derivatives and compositions comprising and methods of using the same SLC5A2, PPARD, DPP4 PPARG 10/4885CYP3A4 108/4885RXRA 213/4885
US-20170049762-A1 5-DEUTERO-2,4-THIAZOLIDINEDIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME SLC5A2, PPARD, DPP4 PPARG 10/4885CYP3A4 108/4885RXRA 213/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.