Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 3/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.40 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928898 | 0.89 | GRM5 (0.48) | GRM5MAOBPARP10NR4A2SGMS2 | |
| SCHEMBL6929584 | 0.87 | GRM5 (0.47) | GRM5MAOBSGMS2MRGPRX4 | |
| SCHEMBL6927929 | 0.86 | GRM5 (0.46) | GRM5MAOBNR4A2SGMS2MRGPRX4 | |
| SCHEMBL2158904 | 0.83 | GRM5 (0.68) | GRM5MAOB | |
| SCHEMBL6929950 | 0.76 | GRM5 (0.54) | GRM5MAOBPARP10NR4A2SGMS2 | |
| SCHEMBL6929270 | 0.74 | GRM5 (0.47) | GRM5MAOBMRGPRX4 | |
| SCHEMBL6931129 | 0.73 | GRM5 (0.51) | GRM5MAOB | |
| SCHEMBL6929241 | 0.73 | GRM5 (0.55) | GRM5 | |
| SCHEMBL9990257 | 0.73 | MRGPRX4 (0.44) | GRM5NR4A2MRGPRX4 | |
| SCHEMBL6930489 | 0.72 | MEN1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011035324-A1 | O-BENZYL NICOTINAMIDE ANALOGS AS MGLUR5 POSITIVE ALLOSTERIC MODULATORS | VANDERBILT UNIVERSITY (US) | 2011-03-24 | — | — | WO | disclosed |