Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Polythiazide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 2/20 | 0.76 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.76 |
| ▸ | CA7 | P43166 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 6/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | CA6 | P23280 | 1/20 | 0.39 |
| ▸ | CA5A | P35218 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Polythiazide SCHEMBL27909 | 0.96 | CHRM1 (0.69) | CHRM1ADRA1ACA7TDP1CYP2C9 | |
| Polythiazide SCHEMBL27910 | 0.96 | CHRM1 (0.69) | CHRM1ADRA1ACA7TDP1CYP2C9 | |
| Polythiazide SCHEMBL29360913 | 0.96 | CHRM1 (0.69) | CHRM1ADRA1ACA7TDP1CYP2C9 | |
| Polythiazide SCHEMBL7254498 | 0.95 | CHRM1 (0.67) | CHRM1ADRA1ACA7TDP1CYP2C9 | |
| Methyclothiazide SCHEMBL49396 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACA7TDP1CYP2C9 | |
| Methyclothiazide SCHEMBL27178 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACA7TDP1CYP2C9 | |
| Methyclothiazide SCHEMBL8051136 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACA7TDP1CYP2C9 | |
| Methyclothiazide SCHEMBL1819665 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACA7TDP1CYP2C9 | |
| Methyclothiazide SCHEMBL29363642 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACA7TDP1CYP2C9 | |
| Methyclothiazide SCHEMBL8065909 | 0.87 | CHRM1 (1.00) | CHRM1ADRA1ACA7TDP1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1257560-A4 | BCL-2-LIKE POLYNUCLEOTIDES, POLYPEPTIDES, AND ANTIBODIES | HUMAN GENOME SCIENCES INC (US) | 2003-10-01 | — | — | EP | disclosed |
| WO-2003031586-A2 | ACRP30-LIKE POLYNUCLEOTIDES, POLYPEPTIDES, AND ANTIBODIES | HUMAN GENOME SCIENCES INC. (US) | 2003-04-17 | — | — | WO | disclosed |
| EP-1259642-A1 | NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES | HUMAN GENOME SCIENCES, INC. (US) | 2002-11-27 | — | — | EP | disclosed |
| EP-1257560-A1 | BCL-2-LIKE POLYNUCLEOTIDES, POLYPEPTIDES, AND ANTIBODIES | HUMAN GENOME SCIENCES, INC. (US) | 2002-11-20 | — | — | EP | disclosed |
| WO-2001057060-A1 | BCL-2-LIKE POLYNUCLEOTIDES, POLYPEPTIDES, AND ANTIBODIES | HUMAN GENOME SCIENCES, INC. (US) | 2001-08-09 | — | — | WO | disclosed |
| WO-2001055448-A1 | NUCLEIC ACIDS, PROTEINS, AND ANTIBODIES | HUMAN GENOME SCIENCES, INC. (US) | 2001-08-02 | — | — | WO | disclosed |