Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 13/20 | 0.51 |
| ▸ | PPARA | Q07869 | 2/20 | 0.51 |
| ▸ | MPC2 | O95563 | 1/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6930655 | 0.91 | PPARG (0.55) | PPARGFFAR1PPARAMPC2CYP2C8 | |
| SCHEMBL19217650 | 0.90 | PPARG (0.56) | PPARGFFAR1PPARAMPC2CYP2C8 | |
| SCHEMBL15811618 | 0.88 | PPARG (0.72) | PPARGFFAR1PPARAMPC2CYP2C8 | |
| SCHEMBL14213672 | 0.85 | PPARG (0.38) | PPARGFFAR1PPARAMPC2CYP2C8 | |
| SCHEMBL6930334 | 0.83 | PPARG (0.52) | PPARGFFAR1PPARA | |
| SCHEMBL6930214 | 0.83 | FFAR1 (0.62) | PPARGFFAR1PPARA | |
| SCHEMBL6930264 | 0.82 | PPARG (0.58) | PPARGFFAR1PPARAMPC2CYP2C8 | |
| SCHEMBL6930420 | 0.81 | PPARG (0.54) | PPARGFFAR1PPARAMPC2CYP2C8 | |
| SCHEMBL6930335 | 0.81 | PPARG (0.56) | PPARGFFAR1PPARAMPC2CYP2C8 | |
| SCHEMBL6928284 | 0.80 | FFAR1 (0.51) | PPARGFFAR1PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084456-A9 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2012-06-21 | — | — | WO | disclosed |
| WO-2011084453-A1 | PPAR-SPARING THIAZOLIDINEDIONE SALTS FOR THE TREATMENT OF METABOLIC DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011084459-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF OBESITY AND OTHER METABOLIC DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011084456-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) | 2011-07-14 | — | — | WO | disclosed |
| WO-2011075514-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) | 2011-06-23 | — | — | WO | disclosed |