Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Gemifloxacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 6/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 0.93 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.93 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.93 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.93 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | ATP6V1B2 | P21281 | 1/20 | 0.43 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.43 |
| ▸ | TOP2A | P11388 | 1/20 | 0.43 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | FLT4 | P35916 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gemifloxacin SCHEMBL136635 | 1.00 | DPP4 (1.00) | DPP4CHRM2DRD1LMNAKDM4E | |
| Gemifloxacin SCHEMBL29662144 | 1.00 | DPP4 (1.00) | DPP4CHRM2DRD1LMNAKDM4E | |
| Gemifloxacin SCHEMBL13414391 | 1.00 | DPP4 (1.00) | DPP4CHRM2DRD1LMNAKDM4E | |
| Gemifloxacin SCHEMBL2419850 | 1.00 | DPP4 (1.00) | DPP4CHRM2DRD1LMNAKDM4E | |
| Gemifloxacin SCHEMBL136634 | 1.00 | DPP4 (1.00) | DPP4CHRM2DRD1LMNAKDM4E | |
| Gemifloxacin SCHEMBL3252334 | 1.00 | DPP4 (1.00) | DPP4CHRM2DRD1LMNAKDM4E | |
| Gemifloxacin SCHEMBL1444728 | 1.00 | DPP4 (1.00) | DPP4CHRM2DRD1LMNAKDM4E | |
| Gemifloxacin SCHEMBL1950144 | 1.00 | DPP4 (1.00) | DPP4CHRM2DRD1LMNAKDM4E | |
| Gemifloxacin SCHEMBL136633 | 1.00 | DPP4 (1.00) | DPP4CHRM2DRD1LMNAKDM4E | |
| Gemifloxacin SCHEMBL1948042 | 0.99 | DPP4 (0.98) | DPP4CHRM2DRD1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242079-A4 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINTS BACTERIA | SMITHKLINE BEECHAM (US) | 2003-01-22 | — | — | EP | disclosed |
| EP-1242079-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINTS BACTERIA | Smithkline Beecham (US) | 2002-09-25 | — | — | EP | disclosed |
| WO-2001021176-A1 | METHODS OF USE OF FLUOROQUINOLONE COMPOUNDS AGAINST BACTERIA | SMITHKLINE BEECHAM CORPORATION (US) | 2001-03-29 | — | — | WO | disclosed |