Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 9/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MPC2 | O95563 | 1/20 | 0.31 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.31 |
| ▸ | PRKCA | P17252 | 1/20 | 0.30 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6928360 | 0.88 | PPARG (0.36) | PPARGCYP3A4RXRAHSD11B1MEN1 | |
| SCHEMBL21504836 | 0.81 | PPARG (0.39) | PPARGCYP3A4RXRAHSD11B1MEN1 | |
| SCHEMBL12515425 | 0.81 | PPARG (0.41) | PPARGCYP3A4RXRAHSD11B1LMNA | |
| SCHEMBL19217815 | 0.81 | PPARG (0.35) | PPARGCYP3A4RXRAHSD11B1MEN1 | |
| SCHEMBL19217615 | 0.80 | PPARG (0.38) | PPARGCYP3A4RXRAHSD11B1MPC2 | |
| SCHEMBL6928382 | 0.80 | PPARG (0.38) | PPARGCYP3A4RXRAHSD11B1MPC2 | |
| SCHEMBL6928329 | 0.80 | PPARG (0.38) | PPARGCYP3A4RXRAHSD11B1MPC2 | |
| SCHEMBL17546497 | 0.79 | PPARG (0.45) | PPARGCYP3A4RXRAHSD11B1MEN1 | |
| SCHEMBL6930392 | 0.78 | PPARG (0.36) | PPARGCYP3A4RXRAHSD11B1MPC2 | |
| SCHEMBL16491936 | 0.78 | PPARG (0.37) | PPARGCYP3A4RXRAHSD11B1MPC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011084456-A9 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY, LLC (US) | 2012-06-21 | — | — | WO | disclosed |
| WO-2011084456-A1 | PPAR-SPARING THIAZOLIDINEDIONES AND COMBINATIONS FOR THE TREATMENT OF DIABETES MELLITUS AND OTHER METABOLIC DISEASES | METABOLIC SOLUTIONS DEVELOPMENT COMPANY (US) | 2011-07-14 | — | — | WO | disclosed |