Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 19/20 | 1.00 |
| ▸ | PRKACA | P17612 | 4/20 | 0.72 |
| ▸ | PRKACG | P22612 | 4/20 | 0.72 |
| ▸ | PRKACB | P22694 | 4/20 | 0.72 |
| ▸ | CDK1 | P06493 | 3/20 | 0.72 |
| ▸ | SRC | P12931 | 3/20 | 0.72 |
| ▸ | AKT2 | P31751 | 3/20 | 0.72 |
| ▸ | AKT3 | Q9Y243 | 3/20 | 0.72 |
| ▸ | PRKCG | P05129 | 2/20 | 0.72 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.72 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.72 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.72 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.72 |
| ▸ | PIM1 | P11309 | 2/20 | 0.72 |
| ▸ | GSK3A | P49840 | 2/20 | 0.72 |
| ▸ | GSK3B | P49841 | 2/20 | 0.72 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.72 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.72 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6854567 | 1.00 | AKT1 (1.00) | AKT1PRKACAPRKACGPRKACBCDK1 | |
| SCHEMBL6854560 | 1.00 | AKT1 (1.00) | AKT1PRKACAPRKACGPRKACBCDK1 | |
| SCHEMBL6855526 | 0.89 | AKT1 (0.82) | AKT1PRKACAPRKACGPRKACBCDK1 | |
| SCHEMBL6853331 | 0.87 | AKT1 (1.00) | AKT1PRKACAPRKACGPRKACBCDK1 | |
| SCHEMBL6856065 | 0.86 | AKT1 (0.76) | AKT1PRKACAPRKACGPRKACBCDK1 | |
| SCHEMBL6855488 | 0.84 | AKT1 (1.00) | AKT1PRKACAPRKACGPRKACBCDK1 | |
| SCHEMBL6854467 | 0.84 | AKT1 (1.00) | AKT1PRKACAPRKACGPRKACBCDK1 | |
| SCHEMBL6854499 | 0.83 | AKT1 (1.00) | AKT1PRKACAPRKACGPRKACBCDK1 | |
| SCHEMBL6855461 | 0.83 | AKT1 (1.00) | AKT1PRKACAPRKACGPRKACBCDK1 | |
| SCHEMBL6855412 | 0.82 | AKT1 (1.00) | AKT1PRKACAPRKACGPRKACBCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1463505-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | Abbott Laboratories (US) | 2004-10-06 | — | — | EP | disclosed |
| WO-2003051366-A2 | 3-(PHENYL-ALKOXY)-5-(PHENYL)-PYRIDINE DERIVATIVES AND RELATED COMPOUNDS AS KINASE INHIBITORS FOR THE TREATMENT OF CANCER | ABBOTT LABORATORIES (US) | 2003-06-26 | — | — | WO | disclosed |