SCHEMBL693203

SCHEMBL693203

Cc1cc(C)cc(Oc2ccc(C#N)cc2S(=O)(=O)N2CCN(C(=O)CC(C)(C)C)CC2)c1

nearest known ligand 0.46

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 10/20 0.46
GAA P10253 2/20 0.42
ALDH1A1 P00352 2/20 0.42
PKM P14618 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
CNR1 P21554 1/20 0.41
CYP3A4 P08684 1/20 0.41
CYP2C19 P33261 1/20 0.41
NPC1 O15118 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15197153 0.94 CNR1 (0.46) TBXA2RGAAALDH1A1CNR1CYP3A4
SCHEMBL694163 0.91 TBXA2R (0.45) TBXA2RGAAALDH1A1PKMSMN1; SMN2
SCHEMBL693463 0.90 CNR1 (0.52) TBXA2RGAAALDH1A1PKMSMN1; SMN2
SCHEMBL694110 0.89 NPC1 (0.50) TBXA2RGAAALDH1A1PKMSMN1; SMN2
SCHEMBL3110767 0.88 TBXA2R (0.48) TBXA2RGAA
SCHEMBL12693469 0.88 TBXA2R (0.47) TBXA2RGAAALDH1A1
SCHEMBL693589 0.87 TBXA2R (0.45) TBXA2RCYP3A4CYP2C19
SCHEMBL2820705 0.86 TBXA2R (0.46) TBXA2R
SCHEMBL12693493 0.85 TBXA2R (0.48) TBXA2RGAAPKM
SCHEMBL16716753 0.85 TBXA2R (0.44) TBXA2RGAAPKM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2502921-B1 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS INC (US) 2015-05-20 EP disclosed
EP-2502921-B1 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS INC (US) 2015-05-20 EP disclosed
US-8658642-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2014-02-25 US disclosed
US-8658642-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2014-02-25 US disclosed
US-8658642-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2014-02-25 US disclosed
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-08-22 US disclosed
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-08-22 US disclosed
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2013-08-22 US disclosed
US-8420639-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2013-04-16 US disclosed
US-8420639-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2013-04-16 US disclosed
US-8420639-B2 Arylsulfonamide CCR3 antagonists AXIKIN PHARMACEUTICALS, INC. (US) 2013-04-16 US disclosed
EP-2502921-A1 Arylsulfonamide CCR3 antagonists Axikin Pharmaceuticals, Inc. (US) 2012-09-26 EP disclosed
EP-2502921-A1 Arylsulfonamide CCR3 antagonists Axikin Pharmaceuticals, Inc. (US) 2012-09-26 EP disclosed
EP-2421838-A2 ARYLSULFONAMIDE CCR3 ANTAGONISTS Axikin Pharmaceuticals, Inc. (US) 2012-02-29 EP disclosed
US-20100273795-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 US disclosed
US-20100273795-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 US disclosed
US-20100273795-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 US disclosed
WO-2010123960-A2 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 WO disclosed
WO-2010123960-A2 ARYLSULFONAMIDE CCR3 ANTAGONISTS AXIKIN PHARMACEUTICALS, INC. (US) 2010-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100273795-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 TBXA2R 2704/4885GAA 2694/4885ALDH1A1 2454/4885
US-20130217687-A1 ARYLSULFONAMIDE CCR3 ANTAGONISTS CCR3, CCR1, CCR4 TBXA2R 2704/4885GAA 2694/4885ALDH1A1 2454/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.