Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.82 |
| ▸ | HPGD | P15428 | 4/20 | 0.82 |
| ▸ | TSHR | P16473 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | HTT | P42858 | 2/20 | 0.77 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.70 |
| ▸ | RAB9A | P51151 | 3/20 | 0.70 |
| ▸ | USP2 | O75604 | 3/20 | 0.70 |
| ▸ | TP53 | P04637 | 3/20 | 0.70 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.70 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6930439 | 0.91 | KDM4E (0.81) | KDM4EALDH1A1HPGDTSHRMEN1 | |
| SCHEMBL11715392 | 0.84 | KDM4E (0.88) | KDM4EALDH1A1HPGDTSHRMEN1 | |
| Dimethylamine SCHEMBL6932652 | 0.82 | KDM4E (0.79) | KDM4EALDH1A1HPGDTSHRMEN1 | |
| Hydrochloric Acid SCHEMBL11715153 | 0.82 | KDM4E (0.84) | KDM4EALDH1A1HPGDTSHRMEN1 | |
| SCHEMBL11718879 | 0.82 | IRAK4 (0.79) | KDM4EALDH1A1HPGDTSHRMEN1 | |
| SCHEMBL6933206 | 0.81 | KDM4E (0.71) | KDM4EALDH1A1HPGDTSHRMEN1 | |
| SCHEMBL25956639 | 0.79 | IRAK4 (0.89) | KDM4EALDH1A1HPGDPOLBIRAK4 | |
| Hydrochloric Acid SCHEMBL6929904 | 0.79 | KDM4E (0.72) | KDM4EALDH1A1HPGDTSHRMEN1 | |
| SCHEMBL20715608 | 0.79 | NPC1 (0.70) | ALDH1A1MEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL11703846 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1HPGDTSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6660870-B1 | Serotonergic compounds which possess agonist activity at 5-HT2 receptors effectively lower and control normal and elevated IOP and are useful for treating glaucoma | ALCON, INC. (CH) | 2003-12-09 | — | — | US | disclosed |