Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 16/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 3/20 | 0.37 |
| ▸ | PPARG | P37231 | 2/20 | 0.37 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6935813 | 0.94 | PTGER4 (0.58) | PTGER4CYP1A2CYP2D6HTR1AADRA1A | |
| SCHEMBL3563515 | 0.94 | PTGER4 (0.49) | PTGER4CYP1A2CYP2D6HTR1AADRA1A | |
| SCHEMBL3568198 | 0.92 | PTGER4 (0.71) | PTGER4CYP1A2CYP2D6 | |
| SCHEMBL3561182 | 0.88 | PTGER4 (0.55) | PTGER4CYP1A2CYP2D6HTR1AADRA1A | |
| SCHEMBL3570585 | 0.88 | PTGER4 (0.47) | PTGER4CYP1A2CYP2D6HTR1AADRA1A | |
| SCHEMBL3572228 | 0.87 | PTGER4 (0.70) | PTGER4CYP1A2CYP2D6PPARG | |
| SCHEMBL6932891 | 0.87 | PTGER4 (0.50) | PTGER4CYP1A2CYP2D6PPARAPPARG | |
| SCHEMBL3564199 | 0.87 | PTGER4 (0.50) | PTGER4CYP1A2CYP2D6HTR1AADRA1A | |
| SCHEMBL3565194 | 0.86 | PTGER4 (0.59) | PTGER4CYP1A2CYP2D6HTR1AADRA1A | |
| SCHEMBL4617779 | 0.86 | PTGER4 (0.67) | PTGER4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368312-A1 | BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064564-A1 | BENZO'F!ISOINDOLE DERIVATIVES WITH AFFINITY TO THE EP4 RECEPTOR | GLAXO GROUP LIMITED (GB) | 2002-08-22 | — | — | WO | disclosed |