Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 3/20 | 0.53 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.53 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.52 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.45 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.43 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.43 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10622023 | 0.98 | CYP4A11 (0.58) | CYP4A11CA2CYP4F2PLA2G10PLA2G2A | |
| SCHEMBL9761155 | 0.94 | CYP4A11 (0.61) | CYP4A11CA2CYP4F2PLA2G10PLA2G2A | |
| SCHEMBL8684163 | 0.89 | CYP4A11 (0.58) | CYP4A11CA2CYP4F2PLA2G10PLA2G2A | |
| SCHEMBL2633786 | 0.87 | PLA2G10 (0.55) | CYP4A11CA2CYP4F2PLA2G10PLA2G2A | |
| SCHEMBL4037830 | 0.83 | PLA2G10 (0.52) | PLA2G10PLA2G2APARP10CYP17A1ALDH1A1 | |
| SCHEMBL13686091 | 0.83 | CYP4A11 (0.63) | CYP4A11CA2CYP4F2PPARAHSD17B10 | |
| SCHEMBL7028830 | 0.83 | CYP4A11 (0.63) | CYP4A11CA2CYP4F2PPARAHSD17B10 | |
| SCHEMBL5330371 | 0.82 | PLA2G10 (0.50) | CYP4A11PLA2G10PLA2G2APARP10CYP17A1 | |
| SCHEMBL9101894 | 0.82 | PARP10 (0.55) | CA2PLA2G10PLA2G2APARP10DPP4 | |
| SCHEMBL29222811 | 0.82 | PLA2G10 (0.50) | CYP4A11PLA2G10PLA2G2APARP10CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101993416-A | Quinoline compound and preparation method thereof, medicament combination containing compound and application of compound | SHANGHAI INST MATERIA MEDICA | 2011-03-30 | — | — | CN | claimed |
| CN-101993416-B | Quinoline compound and preparation method thereof, medicament combination containing compound and application of compound | SHANGHAI INST MATERIA MEDICA | 2013-09-11 | — | — | CN | disclosed |
| CN-101993416-A | Quinoline compound and preparation method thereof, medicament combination containing compound and application of compound | SHANGHAI INST MATERIA MEDICA | 2011-03-30 | — | — | CN | disclosed |
| EP-0768307-B1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-11-26 | — | — | EP | disclosed |
| EP-0768307-A1 | Heterocyclic tertiary amines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1997-04-16 | — | — | EP | disclosed |