Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 1/20 | 0.54 |
| ▸ | GSR | P00390 | 1/20 | 0.50 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.48 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | CPB2 | Q96IY4 | 9/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.39 |
| ▸ | GABRR1 | P24046 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL165084 | 0.98 | FOLH1 (0.56) | FOLH1GSRRNPEPSLC6A5MMP2 | |
| SCHEMBL164121 | 0.98 | FOLH1 (0.56) | FOLH1GSRRNPEPSLC6A5MMP2 | |
| SCHEMBL168589 | 0.98 | FOLH1 (0.56) | FOLH1GSRRNPEPSLC6A5MMP2 | |
| Methane SCHEMBL15135720 | 0.96 | FOLH1 (0.54) | FOLH1GSRRNPEPSLC6A5MMP2 | |
| Hydrochloric Acid SCHEMBL8332033 | 0.96 | FOLH1 (0.54) | FOLH1GSRRNPEPSLC6A5MMP2 | |
| Hydrochloric Acid SCHEMBL25283310 | 0.96 | FOLH1 (0.54) | FOLH1GSRRNPEPSLC6A5MMP2 | |
| Hydrochloric Acid SCHEMBL2844807 | 0.96 | FOLH1 (0.54) | FOLH1GSRRNPEPSLC6A5MMP2 | |
| Methane SCHEMBL15135721 | 0.96 | FOLH1 (0.54) | FOLH1GSRRNPEPSLC6A5MMP2 | |
| SCHEMBL31642200 | 0.96 | FOLH1 (0.54) | FOLH1GSRRNPEPSLC6A5MMP2 | |
| SCHEMBL30360538 | 0.96 | FOLH1 (0.54) | FOLH1GSRRNPEPSLC6A5MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869969-B1 | PEPTIDE CONJUGATES, USE THEREOF AS A DRUG, AND COMPOSITIONS CONTAINING them | INST EUROPEEN BIOLOG CELLULAIR (FR) | 2003-03-26 | — | — | EP | claimed |