Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | MEN1 | O00255 | 4/20 | 1.00 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.75 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.70 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29941108 | 0.90 | KMT2A (0.82) | KMT2AMEN1AKR1C3ESR2AKR1C1 | |
| SCHEMBL21067983 | 0.90 | KMT2A (0.82) | KMT2AMEN1AKR1C3ESR2AKR1C1 | |
| SCHEMBL13302259 | 0.87 | KMT2A (0.77) | KMT2AMEN1AKR1C3SMN1; SMN2KDM4E | |
| SCHEMBL5915341 | 0.87 | KMT2A (0.77) | KMT2AMEN1AKR1C3ESR2AKR1C1 | |
| SCHEMBL12793350 | 0.87 | KMT2A (0.77) | KMT2AMEN1AKR1C3ESR2AKR1C1 | |
| SCHEMBL17710341 | 0.87 | KMT2A (0.77) | KMT2AMEN1AKR1C3ESR2AKR1C1 | |
| SCHEMBL20389408 | 0.87 | KMT2A (0.77) | KMT2AMEN1AKR1C3ESR2AKR1C1 | |
| SCHEMBL2694482 | 0.87 | MEN1 (0.76) | KMT2AMEN1AKR1C3ESR2AKR1C1 | |
| SCHEMBL4787724 | 0.84 | KMT2A (0.72) | KMT2AMEN1AKR1C3ESR2AKR1C1 | |
| SCHEMBL12793297 | 0.84 | KMT2A (0.72) | KMT2AMEN1AKR1C3SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | Janssen Pharmaceutica N.V. (BE) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010124086-A1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-10-28 | — | — | WO | disclosed |
| EP-1140834-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | Du Pont Pharmaceuticals Company (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000035877-A1 | HETEROCYCLIC PIPERIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | DU PONT PHARMACEUTICALS COMPANY (US) | 2000-06-22 | — | — | WO | disclosed |