Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 14/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.49 |
| ▸ | PDE4A | P27815 | 11/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6657268 | 0.91 | PDE4D (0.49) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7216190 | 0.87 | PDE4D (0.47) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6842079 | 0.87 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| SCHEMBL6653576 | 0.85 | PDE4D (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6655858 | 0.85 | PDE4D (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6843999 | 0.85 | PDE4B (0.46) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6656644 | 0.84 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4C | |
| SCHEMBL6657886 | 0.83 | PDE4D (0.45) | PDE4BPDE4DPDE4APDE4CKMT2A | |
| SCHEMBL6657361 | 0.83 | PDE4B (0.50) | PDE4BPDE4DPDE4APDE4CMAPK1 | |
| SCHEMBL6841935 | 0.83 | PDE4B (0.45) | PDE4BPDE4DPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6531473-B2 | Phosphodiesterase inhibitor; antiinflammatory agents | MERCK PATENT GMBH (DE) | 2003-03-11 | — | — | US | disclosed |
| EP-0738715-B1 | Arylalkyl-pyridazinones | MERCK PATENT GMBH (DE) | 2003-01-29 | — | — | EP | disclosed |
| US-20020111356-A1 | Arylalkylpyridazinones | MERCK KGAA (DE) | 2002-08-15 | — | — | US | disclosed |
| US-6399611-B1 | 2-(4-ETHOXYCARBONYLAMINOBENZYL)-6-(3,4 -DIMETHOXYPHENYL)-2,3,4, 5-TETRAHYDROPYRIDAZIN-3-ONE OR ALTERNATELY BENZYL SUBSTITUTED COMPOUNDS; PHOSPHODIESTERASE IV AND TUMOUR NECROSIS FACTOR INHIBITORS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-06-04 | — | — | US | disclosed |
| EP-0738715-A2 | Arylalkyl-pyridazinones | MERCK PATENT GmbH (DE) | 1996-10-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020111356-A1 | Arylalkylpyridazinones | PDE4A, PDE5A, PDE2A | PDE4B 8/4885PDE4D 10/4885PDE4A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.