SCHEMBL6934748

SCHEMBL6934748

CO/C=C(/C(=O)O)c1ccccc1COc1cccc([C@@H]2C[C@H]2C2CC2=NOC)c1

nearest known ligand 0.39

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
HIF1A Q16665 7/20 0.39
GRIN1 Q05586 3/20 0.33
ALOX5 P09917 1/20 0.32
KDM1A O60341 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8083999 0.85 HIF1A (0.41) HIF1AGRIN1KDM1A
SCHEMBL8083996 0.85 HIF1A (0.41) HIF1AGRIN1KDM1A
SCHEMBL8077602 0.80 HIF1A (0.39) HIF1AKDM1A
SCHEMBL8077603 0.80 HIF1A (0.39) HIF1AKDM1A
SCHEMBL6936973 0.78 HIF1A (0.40) HIF1AALOX5
SCHEMBL8082315 0.78 HIF1A (0.36) HIF1AGRIN1
SCHEMBL8082320 0.78 HIF1A (0.36) HIF1AGRIN1
SCHEMBL8077647 0.78 HIF1A (0.36) HIF1A
SCHEMBL8079208 0.77 HIF1A (0.47) HIF1AKDM1A
SCHEMBL8079209 0.77 HIF1A (0.47) HIF1AKDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1050528-B1 Fungicidal and insecticidal benzyloxy cyclopropyl substituted aromatic compounds DOW AGROSCIENCES LLC (US) 2003-01-22 EP disclosed
US-6335367-B1 Fungicidal and insecticidal benzyloxy cyclopropyl substituted aromatic compounds DOW AGROSCIENCES LLC 2002-01-01 US disclosed
EP-1050528-A1 Fungicidal and insecticidal benzyloxy cyclopropyl substituted aromatic compounds ROHM AND HAAS COMPANY (US) 2000-11-08 EP disclosed