Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 2/20 | 0.47 |
| ▸ | AGXT | P21549 | 2/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2997171 | 0.87 | TAAR1 (0.63) | TAAR1SLC6A3DRD2SLC6A4IDO1 | |
| SCHEMBL3371633 | 0.82 | TAAR1 (0.74) | TAAR1SLC6A3DRD2SLC6A4IDO1 | |
| SCHEMBL16038467 | 0.81 | TAAR1 (0.67) | TAAR1SLC6A3DRD2SLC6A4IDO1 | |
| SCHEMBL79429 | 0.79 | TAAR1 (0.59) | TAAR1SLC6A3DRD2SLC6A4IDO1 | |
| SCHEMBL8727622 | 0.79 | TAAR1 (0.59) | TAAR1SLC6A3DRD2SLC6A4IDO1 | |
| SCHEMBL1317595 | 0.79 | TAAR1 (0.77) | TAAR1SLC6A3DRD2SLC6A4IDO1 | |
| SCHEMBL1047725 | 0.79 | TAAR1 (0.59) | TAAR1SLC6A3DRD2SLC6A4IDO1 | |
| SCHEMBL900638 | 0.79 | TAAR1 (0.59) | TAAR1SLC6A3DRD2SLC6A4IDO1 | |
| SCHEMBL17117518 | 0.79 | TAAR1 (0.59) | TAAR1SLC6A3DRD2SLC6A4IDO1 | |
| SCHEMBL81108 | 0.79 | TAAR1 (0.59) | TAAR1SLC6A3DRD2SLC6A4IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649604-B2 | Analgesics; antidiabetic agents; antiinflamamtory agents | AMGEN INC. | 2003-11-18 | — | — | US | disclosed |
| EP-1314732-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |
| EP-1314731-A2 | Substituted pyrimidine compounds and their use | AMGEN INC. (US) | 2003-05-28 | — | — | EP | disclosed |