Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 4/20 | 0.66 |
| ▸ | LTA4H | P09960 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 3/20 | 0.56 |
| ▸ | MMP7 | P09237 | 1/20 | 0.56 |
| ▸ | MMP9 | P14780 | 1/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | MMP13 | P45452 | 1/20 | 0.56 |
| ▸ | ACE | P12821 | 4/20 | 0.55 |
| ▸ | CPA1 | P15085 | 2/20 | 0.55 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.55 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 2/20 | 0.52 |
| ▸ | MMP3 | P08254 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24764799 | 0.90 | MME (0.61) | MMEACECPA1ACE2 | |
| SCHEMBL24764795 | 0.90 | MME (0.61) | MMEACECPA1ACE2 | |
| SCHEMBL7292059 | 0.85 | MME (0.71) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL30522090 | 0.85 | MME (0.71) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL9069255 | 0.85 | MME (0.71) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL31326264 | 0.84 | MME (0.69) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL15692325 | 0.84 | MME (0.69) | MMELTA4HMMP2MMP7MMP9 | |
| SCHEMBL2622217 | 0.83 | NPSR1 (0.55) | MMEMMP2MMP9ACECPA1 | |
| SCHEMBL9223334 | 0.83 | NPSR1 (0.55) | MMEMMP2MMP9ACECPA1 | |
| SCHEMBL1061398 | 0.83 | NPSR1 (0.55) | MMEMMP2MMP9ACECPA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649414-B1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | ARDENT PHARMACEUTICALS INC (US) | 2003-04-16 | — | — | EP | disclosed |
| US-5854249-A | Opioid diarylmethylpiperazines and piperidines | DELTA PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5658908-A | RECEPTOR BINDING SPECIES FOR MEDIATING ANALGESIA, COMBATTING DRUG ADDICTION, DRUG OVERDOSE | DELTA PHARMACEUTICALS, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0649414-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993015062-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-05 | — | — | WO | disclosed |