Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | LMNA | P02545 | 1/20 | 0.70 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.65 |
| ▸ | KCNK3 | O14649 | 6/20 | 0.60 |
| ▸ | KCNK9 | Q9NPC2 | 6/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.56 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.56 |
| ▸ | RELA | Q04206 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL259364 | 0.86 | MEN1 (0.75) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL21349104 | 0.83 | KMT2A (0.67) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4560198 | 0.81 | KDM4E (0.65) | ALDH1A1RAB9ANPC1HTTKDM4E | |
| SCHEMBL2908619 | 0.81 | MEN1 (0.89) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL682877 | 0.80 | MEN1 (0.71) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL259296 | 0.80 | KMT2A (0.80) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL14308003 | 0.80 | MEN1 (0.66) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL4253897 | 0.79 | KCNK3 (0.93) | MEN1KMT2ARXFP1KCNK3KCNK9 | |
| SCHEMBL23367927 | 0.79 | KMT2A (0.69) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL21620291 | 0.79 | KMT2A (0.69) | MEN1KMT2ASMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114275-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-09-22 | — | — | WO | disclosed |