Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.66 |
| ▸ | MEN1 | O00255 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 7/20 | 0.56 |
| ▸ | RAB9A | P51151 | 7/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13649464 | 0.83 | MAPT (0.72) | MAPTMEN1KMT2ARECQLNPC1 | |
| SCHEMBL2937868 | 0.83 | MAPT (0.72) | MAPTMEN1KMT2ARECQLNPC1 | |
| SCHEMBL8401361 | 0.81 | MAPT (0.69) | MAPTMEN1KMT2ARECQLNPC1 | |
| SCHEMBL12862985 | 0.81 | RECQL (0.78) | MAPTMEN1KMT2ARECQLNPC1 | |
| SCHEMBL8118484 | 0.80 | MAPT (1.00) | MAPTMEN1KMT2ARECQLNPC1 | |
| SCHEMBL31124209 | 0.78 | MAPT (0.66) | MAPTMEN1KMT2ARECQLNPC1 | |
| SCHEMBL11701350 | 0.76 | MEN1 (0.63) | MAPTMEN1KMT2ARECQLNPC1 | |
| SCHEMBL13211952 | 0.76 | MEN1 (0.70) | MAPTMEN1KMT2ARECQLNPC1 | |
| SCHEMBL28366489 | 0.76 | MAPT (0.70) | MAPTMEN1KMT2ARECQLNPC1 | |
| SCHEMBL30466612 | 0.76 | MAPT (0.70) | MAPTMEN1KMT2ARECQLNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011114275-A1 | SPIROCYCLIC COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS AND DIAGNOSTIC PROBES | UNIVERSITY OF BASEL (CH) | 2011-09-22 | — | — | WO | disclosed |