Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAP2K1 | Q02750 | 13/20 | 0.50 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692682 | 0.90 | MAP2K1 (0.49) | ALDH1A1MAP2K1MAP2K2MAPK1 | |
| SCHEMBL693247 | 0.89 | MAP2K1 (0.57) | ALDH1A1MAP2K1MAP2K2 | |
| SCHEMBL693420 | 0.88 | MAP2K1 (0.50) | ALDH1A1MAP2K1MAP2K2KMT2ALMNA | |
| SCHEMBL693674 | 0.87 | MAP2K1 (0.53) | ALDH1A1MAP2K1MAP2K2 | |
| SCHEMBL695312 | 0.87 | MAP2K1 (0.52) | ALDH1A1MAP2K1MAP2K2MAPK1 | |
| SCHEMBL13148371 | 0.86 | MAP2K1 (0.52) | ALDH1A1MAP2K1MAP2K2 | |
| SCHEMBL694662 | 0.86 | MAP2K1 (0.60) | ALDH1A1MAP2K1MAP2K2 | |
| SCHEMBL693258 | 0.85 | MAP2K1 (0.47) | ALDH1A1MAP2K1MAP2K2 | |
| SCHEMBL694244 | 0.85 | MAP2K1 (0.53) | ALDH1A1MAP2K1MAP2K2KMT2ALMNA | |
| SCHEMBL692486 | 0.84 | MAP2K1 (0.61) | MAP2K1MAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421612-A1 | HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS | Novartis AG (CH) | 2012-02-29 | — | — | EP | claimed |
| WO-2010121646-A1 | HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS | NOVARTIS AG (CH) | 2010-10-28 | — | — | WO | claimed |
| EP-2421612-A1 | HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS | Novartis AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121646-A1 | HETEROCYCLIC COMPOUNDS AS MEK INHIBITORS | NOVARTIS AG (CH) | 2010-10-28 | — | — | WO | disclosed |