⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11154159 | 0.64 | — | — | |
| SCHEMBL5696134 | 0.52 | — | — | |
| SCHEMBL726333 | 0.52 | — | — | |
| SCHEMBL10898430 | 0.52 | — | — | |
| SCHEMBL7062497 | 0.52 | — | — | |
| SCHEMBL25404221 | 0.50 | — | — | |
| SCHEMBL19133 | 0.50 | — | — | |
| SCHEMBL7980010 | 0.48 | — | — | |
| SCHEMBL12314575 | 0.48 | — | — | |
| SCHEMBL10830256 | 0.48 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979814-B1 | Improved synthesis of haloformimine compounds | ROHM & HAAS (US) | 2003-10-22 | — | — | EP | claimed |
| US-6207863-B1 | MAINTAINING A PH BETWEEN 2 AND 5 DURING THE HALOGENATION OF FORMIMINES GREATLY INCREASES THE YIELDS OF HALOFORMIMINES AND GREATLY DECREASES THE RATE OF BY-PRODUCT FORMATION. | ROHM AND HAAS COMPANY | 2001-03-27 | — | — | US | claimed |
| EP-0979814-A1 | Improved synthesis of haloformimine compounds | ROHM AND HAAS COMPANY (US) | 2000-02-16 | — | — | EP | claimed |
| EP-0207955-B1 | PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED ISOXAZOLES | ZAMBON S.p.A. (IT) | 1990-02-07 | — | — | EP | claimed |
| US-4772719-A | FROM DIHALOFORMALDOXIME AND ALKYNE, CYCLIZATION | ZAMBON S.P.A. (IT) | 1988-09-20 | — | — | US | claimed |
| EP-0207955-A1 | PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED ISOXAZOLES. | ZAMBON SPA (IT) | 1987-01-14 | — | — | EP | claimed |
| WO-1986003490-A1 | PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED ISOXAZOLES | ZAMBON S.P.A. (IT) | 1986-06-19 | — | — | WO | claimed |
| CN-112645894-B | Method for preparing sulpirazole intermediate 5, 5-dimethyl-4, 5-dihydroisoxazole-3-thiocarboxamidine hydrochloride | 江苏中旗科技股份有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-108026090-B | Isoxazoline substituted benzamides and analogs as pesticides | 先正达参股股份有限公司 | 2021-10-26 | — | — | CN | disclosed |
| CN-113372288-A | Synthetic method of topramezone pesticide intermediate | 安徽久易农业股份有限公司 | 2021-09-10 | — | — | CN | disclosed |
| CN-112645894-A | Method for preparing sulpirazole intermediate 5, 5-dimethyl-4, 5-dihydroisoxazole-3-thiocarboxamidine hydrochloride | 江苏中旗科技股份有限公司 | 2021-04-13 | — | — | CN | disclosed |
| EP-3353172-B1 | ISOXAZOLINE-SUBSTITUTED BENZAMIDES AND ANALOGUES AS INSECTICIDES | SYNGENTA PARTICIPATIONS AG (CH) | 2021-02-24 | — | — | EP | disclosed |
| CN-111346213-A | Tissue protective peptides and peptide analogs for the prevention and treatment of diseases and disorders associated with tissue damage | 阿拉伊姆药品公司 | 2020-06-30 | — | — | CN | disclosed |
| US-4772719-A | FROM DIHALOFORMALDOXIME AND ALKYNE, CYCLIZATION | ZAMBON S.P.A. (IT) | 1988-09-20 | — | — | US | disclosed |
| US-4772719-A | FROM DIHALOFORMALDOXIME AND ALKYNE, CYCLIZATION | ZAMBON S.P.A. (IT) | 1988-09-20 | — | — | US | disclosed |
| EP-0237082-A2 | 3,5-disubstituted 4,5-dihydroisoxazoles as transglutaminase inhibitors | SYNTEX (U.S.A.) INC. (US) | 1987-09-16 | — | — | EP | disclosed |
| EP-0232012-A1 | Dihaloformaldoximes | ROHM AND HAAS COMPANY (US) | 1987-08-12 | — | — | EP | disclosed |
| EP-0207955-A1 | PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED ISOXAZOLES. | ZAMBON SPA (IT) | 1987-01-14 | — | — | EP | disclosed |
| WO-1986003490-A1 | PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED ISOXAZOLES | ZAMBON S.P.A. (IT) | 1986-06-19 | — | — | WO | disclosed |
| US-4391759-A | Process for the preparation of organothioaldoxime compounds | UNION CARBIDE CORPORATION (US) | 1983-07-05 | — | — | US | disclosed |