Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8930546 | 1.00 | MAPT (0.51) | MAPTL3MBTL1MEN1KMT2ACYP3A4 | |
| SCHEMBL20187930 | 0.76 | MAPT (0.40) | MAPTL3MBTL1MEN1KMT2ACYP3A4 | |
| SCHEMBL20188285 | 0.76 | MAPT (0.40) | MAPTL3MBTL1MEN1KMT2ACYP3A4 | |
| SCHEMBL20187928 | 0.76 | MAPT (0.40) | MAPTL3MBTL1MEN1KMT2ACYP3A4 | |
| SCHEMBL8726551 | 0.72 | MAPT (0.71) | MAPTL3MBTL1MEN1KMT2ACYP3A4 | |
| SCHEMBL21237286 | 0.71 | TSHR (0.32) | MAPTL3MBTL1KMT2AALDH1A1KDM4E | |
| SCHEMBL24403839 | 0.70 | PIK3CD (0.35) | — | |
| SCHEMBL4597179 | 0.68 | EHMT2 (0.49) | MEN1KMT2ACYP3A4ALDH1A1HTT | |
| SCHEMBL102314 | 0.68 | EHMT2 (0.49) | MEN1KMT2ACYP3A4ALDH1A1HTT | |
| SCHEMBL4187223 | 0.68 | EHMT2 (0.49) | MEN1KMT2ACYP3A4ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649414-B1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | ARDENT PHARMACEUTICALS INC (US) | 2003-04-16 | — | — | EP | disclosed |
| US-5854249-A | Opioid diarylmethylpiperazines and piperidines | DELTA PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5658908-A | RECEPTOR BINDING SPECIES FOR MEDIATING ANALGESIA, COMBATTING DRUG ADDICTION, DRUG OVERDOSE | DELTA PHARMACEUTICALS, INC. (US) | 1997-08-19 | — | — | US | disclosed |
| EP-0649414-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1993015062-A1 | OPIOID DIARYLMETHYLPIPERAZINES AND PIPERIDINES | THE WELLCOME FOUNDATION LIMITED (GB) | 1993-08-05 | — | — | WO | disclosed |