Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 15/20 | 0.41 |
| ▸ | PDE5A | O76074 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4804103 | 0.80 | PDE10A (0.53) | PDE10A | |
| Lithium SCHEMBL4809234 | 0.76 | PDE10A (0.45) | PDE10AHSD17B10 | |
| Lithium SCHEMBL4810220 | 0.75 | PDE10A (0.54) | PDE10A | |
| SCHEMBL4811610 | 0.74 | PDE10A (0.55) | PDE10A | |
| SCHEMBL4809205 | 0.73 | PDE10A (0.45) | PDE10AHSD17B10 | |
| SCHEMBL4886374 | 0.73 | PDE10A (0.44) | PDE10AHSD17B10 | |
| SCHEMBL4810189 | 0.73 | PDE10A (0.54) | PDE10A | |
| SCHEMBL6939512 | 0.69 | PRKCE (0.38) | PDE10AHSD17B10 | |
| SCHEMBL4816050 | 0.68 | CYP11B1 (0.55) | PDE10AHSD17B10 | |
| SCHEMBL4803475 | 0.68 | CYP11B1 (0.55) | PDE10AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268480-A1 | 8-QUINOLINXANTHINE AND 8-ISOQUINOLINXANTHINE DERIVATIVES AS PDE 5 INHIBITORS | Novartis AG (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001077110-A1 | 8-QUINOLINXANTHINE AND 8-ISOQUINOLINXANTHINE DERIVATIVES AS PDE 5 INHIBITORS | NOVARTIS AG (CH) | 2001-10-18 | — | — | WO | disclosed |