Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Glycinebetaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CPT2 | P23786 | 1/20 | 0.39 |
| ▸ | CPT1A | P50416 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.37 |
| ▸ | BBOX1 | O75936 | 7/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycinebetaine SCHEMBL17363512 | 0.98 | TSHR (0.42) | TSHRCPT2CPT1ALMNAALDH1A1 | |
| Glycinebetaine SCHEMBL2016478 | 0.93 | TSHR (0.46) | TSHRCPT2CPT1ALMNAALDH1A1 | |
| Glycinebetaine SCHEMBL20495956 | 0.90 | TSHR (0.43) | TSHRCPT2CPT1ALMNAALDH1A1 | |
| Glycinebetaine SCHEMBL5904826 | 0.88 | TSHR (0.39) | TSHRCPT2CPT1ALMNAALDH1A1 | |
| Glycinebetaine SCHEMBL6673018 | 0.85 | TSHR (0.50) | TSHRCPT2CPT1ALMNAALDH1A1 | |
| Glycinebetaine SCHEMBL9116728 | 0.85 | TSHR (0.48) | TSHRCPT2CPT1ALMNAALDH1A1 | |
| Glycinebetaine SCHEMBL7739 | 0.84 | — | — | |
| Glycinebetaine SCHEMBL4900209 | 0.84 | — | — | |
| Glycinebetaine SCHEMBL8678519 | 0.84 | TSHR (0.53) | TSHRCPT2CPT1ALMNAALDH1A1 | |
| Glycinebetaine SCHEMBL2803780 | 0.84 | TSHR (0.53) | TSHRCPT2CPT1ALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1035828-B1 | TOPICAL COMPOSITIONS FOR REGULATING THE OILY/SHINY APPEARANCE OF SKIN | PROCTER & GAMBLE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6150403-A | INHIBITING SEBACEOUS GLAND ACTIVITY IN MAMMALIAN SKIN AND SCALP BY TOPICALLY ADMINISTERING DEHYDROACETIC ACID OR SALT AND A DERMATOLOGICALLY ACCEPTABLE CARRIER; TREATING ACNE | THE PROCTER & GAMBLE COMPANY (US) | 2000-11-21 | — | — | US | disclosed |